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Peptide record

TPDB54344

Insulin-like growth factor I Neuropeptide standard

70 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB54344

Peptide_Name

Insulin-like growth factor I

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia PEPlife

Sequence_Type

standard

Has_Modification No

Description A 70-aa standard natural neuropeptide peptide sequence curated from Peptipedia and PEPlife, with an available 3D structural model.

Sequence

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

FASTA

>TPDB54344|Neuropeptide|length=70
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

Formula C331H518N94O101S7

Absent Amino Acids HW

Common Amino Acids G

Mass 7654.74

PI 7.62

Basic Residues 9

Acidic Residues 8

Hydrophobic Residues 24

Net Charge +1

Boman Index 12.31

Hydrophobicity -0.274

Aliphatic Index 60.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 4845

Absorbance 280nm 63.29

Polar Residues 20

number

Amino Acid Distribution

A: 6 R: 6 N: 1 D: 4 C: 6 E: 4 Q: 2 G: 7 H: 0 I: 1 L: 6 K: 3 M: 1 F: 4 P: 5 S: 5 T: 3 W: 0 Y: 3 V: 3

Length

Formula

C331H518N94O101S7

Mass

7654.74

7.62

Net Charge

Boman Index

12.31

Hydrophobicity

-0.274

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ailurus fulgens

Family Insulin

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ailuropoda melanoleuca

Family Insulin

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin-like growth factor 1 receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Insulin

Receptor Lengths 640

Receptor Ligands NP05039 NP05061 NP05130

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Insulin

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family Insulin

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Equus caballus

Family Insulin

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin receptor Insulin-like growth factor 1 receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Insulin

Receptor Lengths 1382 1367

Receptor Ligands NP04866 NP04947 NP05046 NP05065 NP05072 NP05133 NP04866 NP04947 NP05046 NP05065 NP05072 NP05133

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Panthera tigris altaica

Family Insulin

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin-like growth factor 1 receptor

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Insulin

Receptor Lengths 304

Receptor Ligands NP05051

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rhinopithecus roxellana

Family Insulin

Experiment context

3 hours 2 hours

Family

Insulin

Half-life seconds

10800.0 7200.0

Half-life unit

hours

Hydrophobicity

N.A.

Molecular Weight (Daltons)

7649

N.A.

Receptor_Lengths

640 1382 1367 304

Receptor_Ligands

NP05039 NP05061 NP05130 NP04866 NP04947 NP05046 NP05065 NP05072 NP05133 NP05051