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Peptide record

TPDB54148

Insulin A chain Neuropeptide standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB54148

Peptide_Name

Insulin A chain

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GIVEQCCTSICSLYQLENYCN

FASTA

>TPDB54148|Neuropeptide|length=21
GIVEQCCTSICSLYQLENYCN

Formula C99H155N25O35S4

Absent Amino Acids ARDHKMFPW

Common Amino Acids C

Mass 2383.71

PI 3.13

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 7

Net Charge -2

Boman Index 1.94

Hydrophobicity 0.214

Aliphatic Index 88.10

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 3230

Absorbance 280nm 135.50

Polar Residues 13

number

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 0 C: 4 E: 2 Q: 2 G: 1 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 2 V: 1

Length

Formula

C99H155N25O35S4

Mass

2383.71

3.13

Net Charge

-2

Boman Index

1.94

Hydrophobicity

0.214

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Balaenoptera physalus

Family Insulin

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Insulin

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Chlorocebus aethiops

Family Insulin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Gorilla gorilla gorilla

Family Insulin

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin-like growth factor 1 receptor Insulin receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Insulin

Receptor Lengths 1367 1382

Receptor Ligands NP04866 NP04947 NP05046 NP05065 NP05072 NP05133 NP04866 NP04947 NP05046 NP05065 NP05072 NP05133

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ictidomys tridecemlineatus

Family Insulin

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca fascicularis

Family Insulin

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pan troglodytes

Family Insulin

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Physeter macrocephalus

Family Insulin

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Insulin

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pongo pygmaeus

Family Insulin

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryctolagus cuniculus

Family Insulin

Family

Insulin

Receptor_Lengths

1367 1382

Receptor_Ligands

NP04866 NP04947 NP05046 NP05065 NP05072 NP05133