TPDB

3D PDB MODEL

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TPDB ID TPDB54130

Peptide_Name

Insulin A chain Insulin-1 A chain Insulin-2 A chain

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GIVDQCCTSICSLYQLENYCN

FASTA

>TPDB54130|Neuropeptide|length=21
GIVDQCCTSICSLYQLENYCN

Formula C98H153N25O35S4

Absent Amino Acids ARHKMFPW

Common Amino Acids C

Mass 2369.68

PI 3.01

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 7

Net Charge -2

Boman Index 1.15

Hydrophobicity 0.214

Aliphatic Index 88.10

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 3230

Absorbance 280nm 136.31

Polar Residues 13

number

0

A

0

R

2

N

1

D

4

C

1

E

2

Q

1

G

0

H

2

I

2

L

0

K

0

M

0

F

0

P

2

S

1

T

0

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 1 C: 4 E: 1 Q: 2 G: 1 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 2 V: 1

Length

21

Formula

C98H153N25O35S4

Mass

2369.68

PI

3.01

Net Charge

-2

Boman Index

1.15

Hydrophobicity

0.214

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Acomys cahirinus

Family Insulin

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cricetulus longicaudatus

Family Insulin

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin receptor

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Insulin

Receptor Lengths 1372

Receptor Ligands NP05004 NP04998 NP05016 NP05010

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin receptor

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Insulin

Receptor Lengths 1383

Receptor Ligands NP05005 NP04999 NP05017 NP05011

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin receptor

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Insulin

Receptor Lengths 1372

Receptor Ligands NP05004 NP04998 NP05016 NP05010

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin receptor

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Insulin

Receptor Lengths 1383

Receptor Ligands NP05005 NP04999 NP05017 NP05011

Family

Insulin

Receptor_Lengths

1372 1383

Receptor_Ligands

NP05004 NP04998 NP05016 NP05010 NP05005 NP04999 NP05017 NP05011