TPDB

3D PDB MODEL

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TPDB ID TPDB53612

Peptide_Name

Insulin B chain

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 30-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FVNQHLCGSHLVEALYLVCGERGFFYTPKT

FASTA

>TPDB53612|Neuropeptide|length=30
FVNQHLCGSHLVEALYLVCGERGFFYTPKT

Formula C158H234N40O42S2

Absent Amino Acids DIMW

Common Amino Acids L

Mass 3429.96

PI 7.16

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +0

Boman Index 1.70

Hydrophobicity 0.220

Aliphatic Index 84.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 3105

Absorbance 280nm 90.53

Polar Residues 9

number

1

A

1

R

1

N

0

D

2

C

2

E

1

Q

3

G

2

H

0

I

4

L

1

K

0

M

3

F

1

P

1

S

2

T

0

W

2

Y

3

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 0 C: 2 E: 2 Q: 1 G: 3 H: 2 I: 0 L: 4 K: 1 M: 0 F: 3 P: 1 S: 1 T: 2 W: 0 Y: 2 V: 3

Length

30

Formula

C158H234N40O42S2

Mass

3429.96

PI

7.16

Net Charge

+0

Boman Index

1.70

Hydrophobicity

0.220

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Chlorocebus aethiops

Family Insulin

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Elephas maximus

Family Insulin

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Gorilla gorilla gorilla

Family Insulin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Insulin-like growth factor 1 receptor Insulin receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Insulin

Receptor Lengths 1367 1382

Receptor Ligands NP04866 NP04947 NP05046 NP05065 NP05072 NP05133 NP04866 NP04947 NP05046 NP05065 NP05072 NP05133

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca fascicularis

Family Insulin

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pan troglodytes

Family Insulin

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pongo pygmaeus

Family Insulin

Family

Insulin

Receptor_Lengths

1367 1382

Receptor_Ligands

NP04866 NP04947 NP05046 NP05065 NP05072 NP05133