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Peptide record

TPDB53603

Urocortin III Urocortin-3 Blood-Brain Barrier Neuropeptide standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB53603
Urocortin III Urocortin-3
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
BBPpredict Peptipedia
standard
No
A 38-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.
Sequence
FTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQI
Physicochemical Analysis
C185H306N52O51S2
CEGWY
A
4138.90
10.59
4
1
22
+2
0.80
0.447
121.05
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
10
Residue Composition
number
8
A
1
R
5
N
1
D
0
C
0
E
2
Q
0
G
1
H
3
I
6
L
2
K
2
M
2
F
1
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 8 R: 1 N: 5 D: 1 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 3 L: 6 K: 2 M: 2 F: 2 P: 1 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
38
C185H306N52O51S2
4138.90
10.59
+2
0.80
0.447
Linear
Similarity
Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile
N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
92

Assay & Model

Origin/Source
Blood/brain ratio

Source & Reference

NA
B3Pdb

Other

mouse
Intracarotid injection
Permeability
Direct iodination
Evidence 2 Activity

Activity

Neuropeptide

Target

Corticotropin-releasing factor receptor 2
Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Sauvagine/corticotropin-releasing factor/urotensin I
411
NP09856 NP09913 NP09918 NP09922
Additional Detail Fields 4 fields
Sauvagine/corticotropin-releasing factor/urotensin I
Intracarotid injection
411
NP09856 NP09913 NP09918 NP09922