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Peptide record

TPDB52830

Cholecystokinin Cholecystokinin 8 Cholecystokinin-8 Blood-Brain Barrier Neuropeptide Tumor-homing Peptides standard

8 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB52830

Peptide_Name

Cholecystokinin Cholecystokinin 8 Cholecystokinin-8

Activity

Blood-Brain Barrier Neuropeptide Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

B3Pred BBPpredict Peptipedia TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (Blood-Brain Barrier, Neuropeptide, and Tumor-homing Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.

Sequence

DYMGWMDF

FASTA

>TPDB52830|Blood-Brain Barrier;Neuropeptide;Tumor-homing Peptides|length=8
DYMGWMDF

Formula C49H61N9O14S2

Absent Amino Acids ARNCEQHILKPSTV

Common Amino Acids DM

Mass 1064.20

PI 2.92

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 5

Net Charge -2

Boman Index -1.91

Hydrophobicity -0.375

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 656.83

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 2 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0

Length

Formula

C49H61N9O14S2

Mass

1064.20

2.92

Net Charge

-2

Boman Index

-1.91

Hydrophobicity

-0.375

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe

SMILES

O=C(O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(N)CC(=O)O)Cc1ccc(O)cc1)CCSC)Cc3c2ccccc2nc3)CCSC)CC(=O)O)Cc4ccccc4

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Dasyurus viverrinus

Family Gastrin/cholecystokinin

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macropus giganteus

Family Gastrin/cholecystokinin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor

Receptor Organisms Xenopus laevis

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Xenopus laevis

Family Gastrin/cholecystokinin

Receptor Lengths 453

Receptor Ligands NP03868 NP03869

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macropus eugenii

Family Gastrin/cholecystokinin

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Calliphora vomitoria

Family Gastrin/cholecystokinin

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Python molurus

Family Gastrin/cholecystokinin

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Gastrin/cholecystokinin type B receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Gastrin/cholecystokinin

Receptor Lengths 454

Receptor Ligands NP03854 NP03893 NP03901 NP03907 NP03913 NP03923 NP03930 NP03935 NP03944 NP03951 NP03964 NP03801 NP04005

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Canis lupus familiaris Canis lupus familiaris

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Gastrin/cholecystokinin

Receptor Lengths 428 453

Receptor Ligands NP03936 NP03945 NP03924 NP03914 NP03908 NP03902 NP03894 NP03965 NP03952 NP03931 NP03802 NP04006 NP03936 NP03945 NP03924 NP03914 NP03908 NP03902 NP03894 NP03965 NP03952 NP03931

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Gallus gallus

Family Gastrin/cholecystokinin

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Gastrin/cholecystokinin

Receptor Lengths 428 447

Receptor Ligands NP03809 NP03858 NP03896 NP03903 NP03909 NP03915 NP03925 NP03932 NP03937 NP03946 NP03954 NP03968 NP04013 NP04026 NP04029 NP04030 NP04031 NP03809 NP03858 NP03896 NP03903 NP03909 NP03915 NP03925 NP03932 NP03937 NP03946 NP03954 NP03968 NP04013 NP04026 NP04029 NP04030 NP04031

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Lithobates catesbeianus

Family Gastrin/cholecystokinin

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca fascicularis

Family Gastrin/cholecystokinin

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Gastrin/cholecystokinin

Receptor Lengths 436 453

Receptor Ligands NP03942 NP03862 NP03898 NP03918 NP03971 NP03871 NP03872 NP03873 NP03874 NP03875 NP03876 NP03877 NP03878 NP03879 NP03880 NP03881 NP03882 NP03883 NP03884 NP03885 NP03886 NP03942 NP03862 NP03898 NP03918 NP03971 NP03811 NP04015 NP04032 NP03871 NP03872 NP03873 NP03874 NP03875 NP03876 NP03877 NP03878 NP03879 NP03880 NP03881 NP03882 NP03883 NP03884 NP03885 NP03886

Evidence 15 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Gastrin/cholecystokinin type B receptor

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Gastrin/cholecystokinin

Receptor Lengths 452

Receptor Ligands NP03890 NP03943 NP03864 NP03940 NP03948 NP03927 NP03919 NP03911 NP03905 NP03899 NP03973 NP03957 NP03934 NP03812 NP04016

Evidence 16 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Cholecystokinin receptor type A Gastrin/cholecystokinin type B receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Gastrin/cholecystokinin

Receptor Lengths 444 452

Receptor Ligands NP03865 NP03900 NP03906 NP03920 NP03928 NP03974 NP03887 NP03865 NP03900 NP03906 NP03920 NP03928 NP03974 NP03813 NP04017 NP03887

Evidence 17 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Struthio camelus

Family Gastrin/cholecystokinin

Evidence 18 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Trachemys scripta

Family Gastrin/cholecystokinin

Evidence 19 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell, Tumor cell, Tumor vessel

Homing or Targeting Targeting

Target Tumor Breast cancer, Colon cancer, Pancreatic ductal adenocarcinoma

Receptors Biomarker CCK

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Nano-enabled immunotherapy in cancer

Year 2022

Reference

US 11433143 B2

Patent US 11433143 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo 4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell

InVivo Model BALB/c mice

Source Type Phage display library

Conjugate Payload PEGylated cholesterol , indoximod

Conjugate_Payload

PEGylated cholesterol , indoximod

Family

Gastrin/cholecystokinin

InVitro_ExVivo

4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell

InVivo_Model

BALB/c mice

Receptor_Lengths

453 454 428 447 436 452 444

Receptor_Ligands

NP03868 NP03869 NP03854 NP03893 NP03901 NP03907 NP03913 NP03923 NP03930 NP03935 NP03944 NP03951 NP03964 NP03801 NP04005 NP03936 NP03945 NP03924 NP03914 NP03908 NP03902 NP03894 NP03965 NP03952 NP03931 NP03802 NP04006 NP03809 NP03858 NP03896 NP03903 NP03909 NP03915 NP03925 NP03932 NP03937 NP03946 NP03954 NP03968 NP04013 NP04026 NP04029 NP04030 NP04031 NP03942 NP03862 NP03898 NP03918 NP03971 NP03871 NP03872 NP03873 NP03874 NP03875 NP03876 NP03877 NP03878 NP03879 NP03880 NP03881 NP03882 NP03883 NP03884 NP03885 NP03886 NP03811 NP04015 NP04032 NP03890 NP03943 NP03864 NP03940 NP03948 NP03927 NP03919 NP03911 NP03905 NP03899 NP03973 NP03957 NP03934 NP03812 NP04016 NP03865 NP03900 NP03906 NP03920 NP03928 NP03974 NP03887 NP03813 NP04017