TPDB

3D PDB MODEL

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TPDB ID TPDB52512

Peptide_Name

CNP-53

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 53-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

DLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC

FASTA

>TPDB52512|Neuropeptide|length=53
DLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC

Formula C251H416N82O70S3

Absent Amino Acids Q

Common Amino Acids G

Mass 5798.75

PI 10.68

Basic Residues 14

Acidic Residues 4

Hydrophobic Residues 17

Net Charge +8

Boman Index 11.17

Hydrophobicity -0.677

Aliphatic Index 71.89

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 122.70

Polar Residues 10

number

4

A

5

R

2

N

3

D

2

C

1

E

0

Q

8

G

2

H

1

I

7

L

7

K

1

M

1

F

1

P

4

S

1

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 4 R: 5 N: 2 D: 3 C: 2 E: 1 Q: 0 G: 8 H: 2 I: 1 L: 7 K: 7 M: 1 F: 1 P: 1 S: 4 T: 1 W: 1 Y: 1 V: 1

Length

53

Formula

C251H416N82O70S3

Mass

5798.75

PI

10.68

Net Charge

+8

Boman Index

11.17

Hydrophobicity

-0.677

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 2 Atrial natriuretic peptide receptor 3

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Natriuretic peptide

Receptor Lengths 1047 536

Receptor Ligands NP06599 NP06607 NP06617 NP06439 NP06494 NP06483 NP06450 NP06461 NP06595 NP06745 NP06599 NP06607 NP06617 NP06472 NP06505 NP06516 NP06666 NP06683 NP06736 NP06768 NP06791

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Natriuretic peptide

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 2 Atrial natriuretic peptide receptor 3

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Natriuretic peptide

Receptor Lengths 1047 535

Receptor Ligands NP06601 NP06609 NP06619 NP06442 NP06453 NP06464 NP06475 NP06486 NP06497 NP06596 NP06747 NP06601 NP06609 NP06619 NP06508 NP06519 NP06669 NP06686 NP06739 NP06771 NP06794

Family

Natriuretic peptide

Receptor_Lengths

1047 536 535

Receptor_Ligands

NP06599 NP06607 NP06617 NP06439 NP06494 NP06483 NP06450 NP06461 NP06595 NP06745 NP06472 NP06505 NP06516 NP06666 NP06683 NP06736 NP06768 NP06791 NP06601 NP06609 NP06619 NP06442 NP06453 NP06464 NP06475 NP06486 NP06497 NP06596 NP06747 NP06508 NP06519 NP06669 NP06686 NP06739 NP06771 NP06794