TPDB

3D PDB MODEL

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TPDB ID TPDB52391

Peptide_Name

Melanin-concentrating hormone

Activity

Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

B3Pred BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.

Sequence

DFDMLRCMLGRVYRPCWQV

FASTA

>TPDB52391|Blood-Brain Barrier;Neuropeptide|length=19
DFDMLRCMLGRVYRPCWQV

Formula C105H162N30O26S4

Absent Amino Acids ANEHIKST

Common Amino Acids R

Mass 2388.87

PI 8.28

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 9

Net Charge +1

Boman Index 0.09

Hydrophobicity -0.032

Aliphatic Index 71.58

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 297.84

Polar Residues 4

number

0

A

3

R

0

N

2

D

2

C

0

E

1

Q

1

G

0

H

0

I

2

L

0

K

2

M

1

F

1

P

0

S

0

T

1

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 2 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 0 M: 2 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 2

Length

19

Formula

C105H162N30O26S4

Mass

2388.87

PI

8.28

Net Charge

+1

Boman Index

0.09

Hydrophobicity

-0.032

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Melanin-concentrating hormone

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanin-concentrating hormone receptor 1 Melanin-concentrating hormone receptor 2

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Melanin-concentrating hormone

Receptor Lengths 422 340

Receptor Ligands NP05382 NP05398 NP05409 NP05414 NP05382 NP05398 NP05409 NP05414

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanin-concentrating hormone receptor 1

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Melanin-concentrating hormone

Receptor Lengths 353

Receptor Ligands NP05383 NP05399 NP05410 NP05416 NP05421

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanin-concentrating hormone receptor 1

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Melanin-concentrating hormone

Receptor Lengths 353

Receptor Ligands NP05394 NP05385 NP05400 NP05411 NP05420 NP05422 NP05423

Family

Melanin-concentrating hormone

Receptor_Lengths

422 340 353

Receptor_Ligands

NP05382 NP05398 NP05409 NP05414 NP05383 NP05399 NP05410 NP05416 NP05421 NP05394 NP05385 NP05400 NP05411 NP05420 NP05422 NP05423