TPDB

3D PDB MODEL

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TPDB ID TPDB52290

Peptide_Name

Melanocyte-stimulating hormone beta

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

DEGPYRMEHFRWGSPPKD

FASTA

>TPDB52290|Neuropeptide|length=18
DEGPYRMEHFRWGSPPKD

Formula C98H138N28O29S1

Absent Amino Acids ANCQILTV

Common Amino Acids P

Mass 2204.40

PI 5.39

Basic Residues 4

Acidic Residues 4

Hydrophobic Residues 4

Net Charge -1

Boman Index 7.42

Hydrophobicity -1.889

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 317.09

Polar Residues 2

number

0

A

2

R

0

N

2

D

0

C

2

E

0

Q

2

G

1

H

0

I

0

L

1

K

1

M

1

F

3

P

1

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 2 C: 0 E: 2 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 1 M: 1 F: 1 P: 3 S: 1 T: 0 W: 1 Y: 1 V: 0

Length

18

Formula

C98H138N28O29S1

Mass

2204.40

PI

5.39

Net Charge

-1

Boman Index

7.42

Hydrophobicity

-1.889

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family POMC

Receptor Lengths 323 332 325 317

Receptor Ligands NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocyte-stimulating hormone receptor

Receptor Organisms Macaca nemestrina

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca nemestrina

Family POMC

Receptor Lengths 317

Receptor Ligands NP09138 NP08985 NP09088 NP09113

Family

POMC

Receptor_Lengths

323 332 325 317

Receptor_Ligands

NP08981 NP09084 NP09109 NP09136 NP09173 NP09034 NP09035 NP09138 NP08985 NP09088 NP09113