TPDB

3D PDB MODEL

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TPDB ID TPDB52188

Peptide_Name

Arg-vasopressin

Activity

Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

B3Pred BBPpredict Peptipedia PEPlife

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.

Sequence

CYFQNCPRG

FASTA

>TPDB52188|Blood-Brain Barrier;Neuropeptide|length=9
CYFQNCPRG

Formula C46H66N14O13S2

Absent Amino Acids ADEHILKMSTWV

Common Amino Acids C

Mass 1087.24

PI 8.28

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index -0.28

Hydrophobicity -0.778

Aliphatic Index 0.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 148.54

Polar Residues 5

number

0

A

1

R

1

N

0

D

2

C

0

E

1

Q

1

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

9

Formula

C46H66N14O13S2

Mass

1087.24

PI

8.28

Net Charge

+1

Boman Index

-0.28

Hydrophobicity

-0.778

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Balaenoptera physalus

Family Vasopressin/oxytocin

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasopressin V2 receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Vasopressin/oxytocin

Receptor Lengths 370

Receptor Ligands NP11091

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family Vasopressin/oxytocin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasopressin V1a receptor Vasopressin V1b receptor Vasopressin V2 receptor Oxytocin receptor

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Vasopressin/oxytocin

Receptor Lengths 418 424 371 389

Receptor Ligands NP11093 NP11093 NP11093 NP11093 NP11194

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasopressin V1a receptor Vasopressin V1b receptor Vasopressin V2 receptor

Receptor Organisms Mus musculus Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Vasopressin/oxytocin

Receptor Lengths 423 421 371

Receptor Ligands NP11094 NP11094 NP11094

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasopressin V1a receptor Vasopressin V1b receptor Vasopressin V2 receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Vasopressin/oxytocin

Receptor Lengths 424 425 371

Receptor Ligands NP11095 NP11095 NP11095

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasopressin V1a receptor

Receptor Organisms Ovis aries

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Vasopressin/oxytocin

Receptor Lengths 418

Receptor Ligands NP11096

Experiment context

10-20 minutes

Family

Vasopressin/oxytocin

Half-life seconds

900.0

Half-life unit

minutes

Hydrophobicity

-4.9

Molecular Weight (Daltons)

1050.215

pI

N.A.

Receptor_Lengths

370 418 424 371 389 423 421 425

Receptor_Ligands

NP11091 NP11093 NP11194 NP11094 NP11095 NP11096