TPDB

3D PDB MODEL

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TPDB ID TPDB52176

Peptide_Name

Endothelin-2

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

CSCSSWLDKECVYFCHLDIIW

FASTA

>TPDB52176|Neuropeptide|length=21
CSCSSWLDKECVYFCHLDIIW

Formula C115H164N26O32S4

Absent Amino Acids ARNQGMPT

Common Amino Acids C

Mass 2550.96

PI 4.30

Basic Residues 2

Acidic Residues 3

Hydrophobic Residues 9

Net Charge -2

Boman Index -1.58

Hydrophobicity 0.500

Aliphatic Index 88.10

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 12740

Absorbance 280nm 499.42

Polar Residues 8

number

0

A

0

R

0

N

2

D

4

C

1

E

0

Q

0

G

1

H

2

I

2

L

1

K

0

M

1

F

0

P

3

S

0

T

2

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 4 E: 1 Q: 0 G: 0 H: 1 I: 2 L: 2 K: 1 M: 0 F: 1 P: 0 S: 3 T: 0 W: 2 Y: 1 V: 1

Length

21

Formula

C115H164N26O32S4

Mass

2550.96

PI

4.30

Net Charge

-2

Boman Index

-1.58

Hydrophobicity

0.500

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Endothelin/sarafotoxin

Receptor Lengths 441

Receptor Ligands NP02556 NP02568 NP02545

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Canis lupus familiaris

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Endothelin/sarafotoxin

Receptor Lengths 442

Receptor Ligands NP02557 NP02569 NP02578 NP02546

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Felis catus

Family Endothelin/sarafotoxin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Equus caballus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Equus caballus

Family Endothelin/sarafotoxin

Receptor Lengths 443

Receptor Ligands NP02571

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin-1 receptor Endothelin receptor type B

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Endothelin/sarafotoxin

Receptor Lengths 427 442

Receptor Ligands NP02572 NP02579 NP02549 NP02560 NP02572 NP02579 NP02549 NP02560

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mustela putorius furo

Family Endothelin/sarafotoxin

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Oryctolagus cuniculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryctolagus cuniculus

Family Endothelin/sarafotoxin

Receptor Lengths 441

Receptor Ligands NP02564 NP02576 NP02582 NP02552

Family

Endothelin/sarafotoxin

Receptor_Lengths

441 442 443 427

Receptor_Ligands

NP02556 NP02568 NP02545 NP02557 NP02569 NP02578 NP02546 NP02571 NP02572 NP02579 NP02549 NP02560 NP02564 NP02576 NP02582 NP02552