TPDB

3D PDB MODEL

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TPDB ID TPDB52169

Peptide_Name

Endothelin-3

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

CTCFTYKDKECVYYCHLDIIW

FASTA

>TPDB52169|Neuropeptide|length=21
CTCFTYKDKECVYYCHLDIIW

Formula C121H172N26O33S4

Absent Amino Acids ARNQGMPS

Common Amino Acids C

Mass 2647.09

PI 5.27

Basic Residues 3

Acidic Residues 3

Hydrophobic Residues 9

Net Charge -1

Boman Index -0.17

Hydrophobicity 0.100

Aliphatic Index 69.52

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 10220

Absorbance 280nm 386.08

Polar Residues 9

number

0

A

0

R

0

N

2

D

4

C

1

E

0

Q

0

G

1

H

2

I

1

L

2

K

0

M

1

F

0

P

0

S

2

T

1

W

3

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 4 E: 1 Q: 0 G: 0 H: 1 I: 2 L: 1 K: 2 M: 0 F: 1 P: 0 S: 0 T: 2 W: 1 Y: 3 V: 1

Length

21

Formula

C121H172N26O33S4

Mass

2647.09

PI

5.27

Net Charge

-1

Boman Index

-0.17

Hydrophobicity

0.100

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Canis lupus familiaris

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Endothelin/sarafotoxin

Receptor Lengths 442

Receptor Ligands NP02557 NP02569 NP02578 NP02546

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin-1 receptor Endothelin receptor type B

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Endothelin/sarafotoxin

Receptor Lengths 427 442

Receptor Ligands NP02572 NP02579 NP02549 NP02560 NP02572 NP02579 NP02549 NP02560

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Endothelin/sarafotoxin

Receptor Lengths 442

Receptor Ligands NP02562 NP02574 NP02580 NP02550

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Endothelin/sarafotoxin

Receptor Lengths 443

Receptor Ligands NP02551 NP02563 NP02581

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Oryctolagus cuniculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryctolagus cuniculus

Family Endothelin/sarafotoxin

Receptor Lengths 441

Receptor Ligands NP02564 NP02576 NP02582 NP02552

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Endothelin receptor type B

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Endothelin/sarafotoxin

Receptor Lengths 442

Receptor Ligands NP02565 NP02577 NP02583 NP02553

Family

Endothelin/sarafotoxin

Receptor_Lengths

442 427 443 441

Receptor_Ligands

NP02557 NP02569 NP02578 NP02546 NP02572 NP02579 NP02549 NP02560 NP02562 NP02574 NP02580 NP02550 NP02551 NP02563 NP02581 NP02564 NP02576 NP02582 NP02552 NP02565 NP02577 NP02583 NP02553