TPDB

3D PDB MODEL

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TPDB ID TPDB51390

Peptide_Name

Pancreatic hormone

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 36-aa standard natural neuropeptide peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY

FASTA

>TPDB51390|Neuropeptide|length=36
APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY

Formula C185H286N52O55S2

Absent Amino Acids CHKFSW

Common Amino Acids AP

Mass 4182.74

PI 6.98

Basic Residues 4

Acidic Residues 4

Hydrophobic Residues 16

Net Charge -0

Boman Index 7.29

Hydrophobicity -0.781

Aliphatic Index 65.28

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5960

Absorbance 280nm 142.49

Polar Residues 10

number

5

A

4

R

2

N

2

D

0

C

2

E

2

Q

1

G

0

H

1

I

3

L

0

K

2

M

0

F

5

P

0

S

2

T

0

W

4

Y

1

V

Amino Acid Distribution

A: 5 R: 4 N: 2 D: 2 C: 0 E: 2 Q: 2 G: 1 H: 0 I: 1 L: 3 K: 0 M: 2 F: 0 P: 5 S: 0 T: 2 W: 0 Y: 4 V: 1

Length

36

Formula

C185H286N52O55S2

Mass

4182.74

PI

6.98

Net Charge

-0

Boman Index

7.29

Hydrophobicity

-0.781

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5 Putative neuropeptide Y receptor type 6 Neuropeptide Y receptor type 4-2

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family NPY

Receptor Lengths 384 381 375 445 290 375

Receptor Ligands NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca mulatta

Family NPY

Family

NPY

Receptor_Lengths

384 381 375 445 290

Receptor_Ligands

NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720