TPDB

3D PDB MODEL

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TPDB ID TPDB51386

Peptide_Name

Pancreatic hormone Pancreatic Polypepti

Activity

Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

BBPpredict Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 36-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from BBPpredict and Peptipedia, with an available 3D structural model.

Sequence

APLEPEYPGDNATPEQMAQYAAELRRYINMLTRPRY

FASTA

>TPDB51386|Blood-Brain Barrier;Neuropeptide|length=36
APLEPEYPGDNATPEQMAQYAAELRRYINMLTRPRY

Formula C186H286N52O57S2

Absent Amino Acids CHKFSWV

Common Amino Acids AP

Mass 4226.75

PI 4.79

Basic Residues 4

Acidic Residues 5

Hydrophobic Residues 15

Net Charge -1

Boman Index 10.03

Hydrophobicity -0.994

Aliphatic Index 57.22

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5960

Absorbance 280nm 141.01

Polar Residues 10

number

5

A

4

R

2

N

1

D

0

C

4

E

2

Q

1

G

0

H

1

I

3

L

0

K

2

M

0

F

5

P

0

S

2

T

0

W

4

Y

0

V

Amino Acid Distribution

A: 5 R: 4 N: 2 D: 1 C: 0 E: 4 Q: 2 G: 1 H: 0 I: 1 L: 3 K: 0 M: 2 F: 0 P: 5 S: 0 T: 2 W: 0 Y: 4 V: 0

Length

36

Formula

C186H286N52O57S2

Mass

4226.75

PI

4.79

Net Charge

-1

Boman Index

10.03

Hydrophobicity

-0.994

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr

SMILES

[H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.32

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family NPY

Family

NPY