TPDB

3D PDB MODEL

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TPDB ID TPDB50661

Peptide_Name

Orexin-A

Activity

Neuropeptide

Activity_category_statistics

Neuroactive peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural neuropeptide peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

FASTA

>TPDB50661|Neuropeptide|length=33
QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

Formula C152H249N47O45S4

Absent Amino Acids MFWV

Common Amino Acids L

Mass 3583.18

PI 7.86

Basic Residues 5

Acidic Residues 2

Hydrophobic Residues 11

Net Charge +1

Boman Index 4.62

Hydrophobicity -0.061

Aliphatic Index 91.82

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 1740

Absorbance 280nm 48.56

Polar Residues 11

number

3

A

2

R

1

N

1

D

4

C

1

E

2

Q

3

G

2

H

1

I

6

L

1

K

0

M

0

F

2

P

1

S

2

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 3 R: 2 N: 1 D: 1 C: 4 E: 1 Q: 2 G: 3 H: 2 I: 1 L: 6 K: 1 M: 0 F: 0 P: 2 S: 1 T: 2 W: 0 Y: 1 V: 0

Length

33

Formula

C152H249N47O45S4

Mass

3583.18

PI

7.86

Net Charge

+1

Boman Index

4.62

Hydrophobicity

-0.061

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Orexin receptor type 1

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Orexin

Receptor Lengths 425

Receptor Ligands NP08528

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Orexin receptor type 2

Receptor Organisms Canis lupus familiaris

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Orexin

Receptor Lengths 444

Receptor Ligands NP08529 NP08534

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Orexin receptor type 1 Orexin receptor type 2

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Orexin

Receptor Lengths 425 444

Receptor Ligands NP08530 NP08535 NP08530 NP08535

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Orexin receptor type 1 Orexin receptor type 2

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Orexin

Receptor Lengths 416 460

Receptor Ligands NP08531 NP08536 NP08531 NP08536

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Orexin receptor type 1 Orexin receptor type 2

Receptor Organisms Sus scrofa Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Orexin

Receptor Lengths 425 444

Receptor Ligands NP08532 NP08537 NP08532 NP08537

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Orexin receptor type 1 Orexin receptor type 2

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Orexin

Receptor Lengths 416 460

Receptor Ligands NP08533 NP08538 NP08526 NP08527 NP08533 NP08538 NP08526 NP08527

Family

Orexin

Receptor_Lengths

425 444 416 460

Receptor_Ligands

NP08528 NP08529 NP08534 NP08530 NP08535 NP08531 NP08536 NP08532 NP08537 NP08533 NP08538 NP08526 NP08527