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Peptide record

TPDB50657

β-Amyloid1-28 Blood-Brain Barrier Neuropeptide standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB50657
β-Amyloid1-28
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
B3Pred BBPpredict Peptipedia pep-lab
standard
No
A 28-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DAEFRHDSGYQVHHQKLVFFAEDVGSNK
Physicochemical Analysis
C145H210N42O45
CIMPTW
DHFV
3261.52
5.76
6
5
10
-2
10.24
-0.900
52.14
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
45.68
6
Residue Composition
number
2
A
1
R
1
N
3
D
0
C
2
E
2
Q
2
G
3
H
0
I
1
L
2
K
0
M
3
F
0
P
2
S
0
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 3 C: 0 E: 2 Q: 2 G: 2 H: 3 I: 0 L: 1 K: 2 M: 0 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 3
Chemical Descriptors
28
C145H210N42O45
3261.52
5.76
-2
10.24
-0.900
Linear
Similarity
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O
Evidence Records 6 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
20.6 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.015 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
-1.53

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.00098 mL/(g x min)

Assay & Model

Capillary deplition in situ b p
Origin/Source
Unidirectonal influx rate constant

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.000386 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Intravenous
non saturable
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.0159 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Intravenous
non saturable
Direct iodination
Additional Detail Fields 1 fields
Intravenous