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Peptide record

TPDB50637

Dynorphin (1-13) Dynorphin A(1-13) Blood-Brain Barrier Neuropeptide standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB50637
Dynorphin (1-13) Dynorphin A(1-13)
Blood-Brain Barrier Neuropeptide
Delivery and barrier-penetrating peptides Neuroactive peptides
B3Pred BBPpredict Peptipedia pep-lab
standard
No
A 13-aa standard natural multi-activity (Blood-Brain Barrier and Neuropeptide) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YGGFLRRIRPKLK
Physicochemical Analysis
C75H126N24O15
ANDCEQHMSTWV
R
1603.98
12.14
5
0
5
+5
1.38
-0.777
90.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
92.89
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C75H126N24O15
1603.98
12.14
+5
1.38
-0.777
Linear
Similarity
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
O=C(NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CCCCN)CC(C)C)CCCCN)CCC1)CCCNC(=[N@H])N)C(C)CC)CCCNC(=[N@H])N)CCCNC(=[N@H])N)CC(C)C)Cc2ccccc2)CNC(=O)C(N)Cc3ccc(O)cc3
Evidence Records 7 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.14%

Assay & Model

BUI method
Origin/Source
BUI

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
H3/C14
Evidence 2 Activity

Activity

Neuropeptide

Target

Kappa-type opioid receptor
Bos taurus

Source & Reference

NA
NeuroPepV2

Other

Bos taurus
Opioid
380
NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979
Evidence 3 Activity

Activity

Neuropeptide

Target

Kappa-type opioid receptor
Cavia porcellus

Source & Reference

NA
NeuroPepV2

Other

Cavia porcellus
Opioid
380
NP07972 NP08004 NP08010 NP08026 NP08033 NP08039 NP07981
Evidence 4 Activity

Activity

Neuropeptide

Target

Delta-type opioid receptor Kappa-type opioid receptor
Homo sapiens Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Opioid
372 380
NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP07982
Evidence 5 Activity

Activity

Neuropeptide

Target

Kappa-type opioid receptor
Mus musculus

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Opioid
380
NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987
Evidence 6 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Sus scrofa
Opioid
Evidence 7 Activity

Activity

Neuropeptide

Target

Delta-type opioid receptor Kappa-type opioid receptor
Rattus norvegicus Rattus norvegicus

Source & Reference

NA
NeuroPepV2

Other

Rattus norvegicus
Opioid
372 380
NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP07992
Additional Detail Fields 3 fields
Opioid
380 372
NP08044 NP07971 NP08003 NP08009 NP08025 NP08032 NP08038 NP07979 NP07972 NP08004 NP08010 NP08026 NP08033 NP08039 NP07981 NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP07982 NP07974 NP08006 NP08012 NP08028 NP08035 NP08041 NP07999 NP07987 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102