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Peptide record

TPDB50563

Antifungal standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB50563
Antifungal
Anti-infective peptides
Peptipedia
standard
No
A 29-aa standard natural antifungal peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
C157H268N48O43
ACHMWY
K
3516.15
11.04
9
4
9
+5
13.17
-0.955
87.24
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
4
R
1
N
1
D
0
C
3
E
1
Q
1
G
0
H
3
I
2
L
5
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 0 E: 3 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 5 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
29
C157H268N48O43
3516.15
11.04
+5
13.17
-0.955
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

NA

Other

SK-29 is active against C. albicans (MIC data not reported). Like LL-37, it also retains ROS stimulation activity from neutrophils. It demonstrated weaker apoptosis inhibitory activity as well as IL-8 release from neutrophils.