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Peptide record

TPDB50529

Antifungal standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB50529
Antifungal
Anti-infective peptides
Peptipedia
standard
No
A 9-aa standard-residue antifungal peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
PQAVIVASG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C37H64N10O12
RNDCEHLKMFTWY
AV
840.98
6.02
0
0
5
-0
-0.96
1.133
130.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
9 reviewed residue count
C37H64N10O12 sequence-only estimate (linear, free termini)
840.98 sequence-only estimate (linear, free termini)
6.02 sequence-only estimate (linear, free termini)
-0 sequence-only estimate (linear, free termini)
-0.96 sequence-only estimate (linear, free termini)
1.133 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antifungal
>64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

NA

Other

Disc diffusion assay: activity was not detected. Microdilution assays: A. niger ATCC 16404 (MIC >64 ug/ml), A. niger 1133 m (MIC >64 ug/ml), A. terreus 3 K (MIC 16 ug/ml), A. terreus 497 (MIC 16 u
Evidence 2 Activity

Activity

MIC
Antifungal
>64 µg/mL

Target

A. niger 1133 m

Source & Reference

NA

Other

ay: activity was not detected. Microdilution assays: A. niger ATCC 16404 (MIC >64 ug/ml), A. niger 1133 m (MIC >64 ug/ml), A. terreus 3 K (MIC 16 ug/ml), A. terreus 497 (MIC 16 ug/ml), A. fumigatus VKM F-37 (MIC
Evidence 3 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

A. terreus 3 K

Source & Reference

NA

Other

crodilution assays: A. niger ATCC 16404 (MIC >64 ug/ml), A. niger 1133 m (MIC >64 ug/ml), A. terreus 3 K (MIC 16 ug/ml), A. terreus 497 (MIC 16 ug/ml), A. fumigatus VKM F-37 (MIC 32 ug/ml), and A. fumigatus 39
Evidence 4 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

A. terreus 497

Source & Reference

NA

Other

CC 16404 (MIC >64 ug/ml), A. niger 1133 m (MIC >64 ug/ml), A. terreus 3 K (MIC 16 ug/ml), A. terreus 497 (MIC 16 ug/ml), A. fumigatus VKM F-37 (MIC 32 ug/ml), and A. fumigatus 390 m (MIC 32 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

A. fumigatus VKM F-37

Source & Reference

NA

Other

ger 1133 m (MIC >64 ug/ml), A. terreus 3 K (MIC 16 ug/ml), A. terreus 497 (MIC 16 ug/ml), A. fumigatus VKM F-37 (MIC 32 ug/ml), and A. fumigatus 390 m (MIC 32 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

A. fumigatus 390 m

Source & Reference

NA

Other

(MIC 16 ug/ml), A. terreus 497 (MIC 16 ug/ml), A. fumigatus VKM F-37 (MIC 32 ug/ml), and A. fumigatus 390 m (MIC 32 ug/ml).