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Peptide record

TPDB50097

Antifungal standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB50097
Antifungal
Anti-infective peptides
Peptipedia
standard
No
A 18-aa standard-residue antifungal peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GVCRCVCRRGVCRCFCRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C82H146N36O19S6
ANDEQHILKMPSTWY
RC
2132.65
9.49
6
0
4
+6
3.60
0.144
48.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
0.18
6
Residue Composition
number
0
A
6
R
0
N
0
D
6
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
18 reviewed residue count
C82H146N36O19S6 sequence-only estimate (linear, free termini)
2132.65 sequence-only estimate (linear, free termini)
9.49 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
3.60 sequence-only estimate (linear, free termini)
0.144 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

MIC
Antifungal
3.1-12.5 µg/mL

Target

Candida albicans clinical isolates

Source & Reference

NA

Other

Active against drug resistant C. albicans clinical isolates (MIC 3.1-12.5 ug/ml). Seq8/2022