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Peptide record

TPDB49966

Antifungal standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB49966
Antifungal
Anti-infective peptides
DRAMP Peptipedia
standard
No
A 14-aa standard natural antifungal peptide sequence curated from DRAMP and Peptipedia, with an available 3D structural model.
Sequence
GIWKFLKKAKKFWK
Physicochemical Analysis
C93H142N22O15
RNDCEQHMPSTYV
K
1808.29
11.21
6
0
7
+6
-1.05
-0.707
62.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
608.31
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
6
K
0
M
2
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C93H142N22O15
1808.29
11.21
+6
-1.05
-0.707
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

S. flexneri

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms.
3 clincial strains B4/B6/B9 (MIC 4-16 ug/ml), E. cloacae S1 or S3 AmpC+ (MIC 4-8 ug/ml), S. flexneri (MIC 8 ug/ml), Gram+ bacteria S. aureus ATCC25923 and 4 clincial strains MSSA/MRSA (MIC 8-16 ug/ml), S.
Evidence 2 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

E. faecium

Source & Reference

DRAMP

Other

8-16 ug/ml), S. pneumoniae ATCC 49619 and 4 clincial strains PISP/PRSP (MIC 8-32 ug/ml), E. faecium (MIC 4 ug/ml), and E. faecalis (MIC 8 ug/ml). MSSA: Methicillin sensitive Staphylococcus aureus MRSA:
Evidence 3 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

CC 49619 and 4 clincial strains PISP/PRSP (MIC 8-32 ug/ml), E. faecium (MIC 4 ug/ml), and E. faecalis (MIC 8 ug/ml). MSSA: Methicillin sensitive Staphylococcus aureus MRSA: Methicillin resistant Staphyloc