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Peptide record

TPDB49912

hCT Antifungal Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB49912
hCT
Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 22-aa standard natural multi-activity (Antifungal and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
LGTYTQDFNKTFPQTAIGVGAP
Physicochemical Analysis
C106H160N26O33
RCEHMSW
T
2326.59
6.68
1
1
8
-0
0.95
-0.214
57.73
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
64.04
8
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
2
Q
3
G
0
H
1
I
1
L
1
K
0
M
2
F
2
P
0
S
4
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 1 L: 1 K: 1 M: 0 F: 2 P: 2 S: 0 T: 4 W: 0 Y: 1 V: 1
Chemical Descriptors
22
C106H160N26O33
2326.59
6.68
-0
0.95
-0.214
Free
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C. Albicans Strain Sc5314 And C. Glabrata Strain Atcc2006

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
5-carboxyfluorescein (FAM) conjugated
Vacuole
hCT (no net charge) could not be detected entering the Candida cells.
In vitro
CCSSCCCCCCCCCCCSSCCCC
Additional Detail Fields 1 fields
CCSSCCCCCCCCCCCSSCCCC