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Peptide record

TPDB49873

VRF007 Antifungal Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB49873
VRF007
Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antifungal and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KDRPIFQLNTSYWEMGA
Physicochemical Analysis
C93H138N24O27S1
CHV
ARNDEQGILKMFPSTWY
2056.32
6.95
2
2
7
-0
1.59
-0.782
51.76
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
339.93
5
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
1
E
1
Q
1
G
0
H
1
I
1
L
1
K
1
M
1
F
1
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 1 K: 1 M: 1 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
17
C93H138N24O27S1
2056.32
6.95
-0
1.59
-0.782
Free
L
Amphiphilic Neutral
Linear
Conjugated with FITC
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Corneal Epithelial Cells Candida Albicans And F. Solani

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
FITC-conjugated
VRF007 were able to penetrate corneal epithelium and C. albicans, but no uptake in F. solani.
In vitro
CCCSTTTTTTTSTTTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Candida Albicans And Fusarium Solani

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Neutral
Synthetic
FITC dye and natamycin
Clathrin mediated endocytosis
In vitro
CCCGGGGCCCC
Additional Detail Fields 1 fields
CCCSTTTTTTTSTTTCC CCCGGGGCCCC