TPDB

3D PDB MODEL

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TPDB ID TPDB49831

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP

Sequence_Type

standard

Has_Modification No

Description A 281-aa standard natural antifungal peptide sequence curated from dbAMP, with an available 3D structural model.

Sequence

MAAKMAKNVDKPLFTATFNVQASSADYATFIAGIRNKLRNPAHFSHNRPVLPPVEPNVPPSRWFHVVLKASPTSAGLTLAIRADNIYLEGFKSSDGTWWELTPGLIPGATYVGFGGTYRDLLGDTDKLTNVALGRQQLADAVTALHGRTKADKPSGPKQQQAREAVTTLLLMVNEATRFQTVSGFVAGLLHPKAVEKKSGKIGNEMKAQVNGWQDLSAALLKTDVKPPPGKSPAKFAPIEKMGVRTAVQAANTLGILLFVEVPGGLTVAKALELFHASGGK

FASTA

>TPDB49831|Antifungal|length=281
MAAKMAKNVDKPLFTATFNVQASSADYATFIAGIRNKLRNPAHFSHNRPVLPPVEPNVPPSRWFHVVLKASPTSAGLTLAIRADNIYLEGFKSSDGTWWELTPGLIPGATYVGFGGTYRDLLGDTDKLTNVALGRQQLADAVTALHGRTKADKPSGPKQQQAREAVTTLLLMVNEATRFQTVSGFVAGLLHPKAVEKKSGKIGNEMKAQVNGWQDLSAALLKTDVKPPPGKSPAKFAPIEKMGVRTAVQAANTLGILLFVEVPGGLTVAKALELFHASGGK

Formula C1352H2158N374O385S5

Absent Amino Acids C

Common Amino Acids A

Mass 29972.58

PI 10.31

Basic Residues 39

Acidic Residues 21

Hydrophobic Residues 119

Net Charge +13

Boman Index 46.03

Hydrophobicity -0.132

Aliphatic Index 86.51

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 27960

Absorbance 280nm 93.29

Polar Residues 61

number

35

A

11

R

12

N

11

D

0

C

10

E

10

Q

25

G

6

H

8

I

29

L

22

K

5

M

12

F

20

P

14

S

21

T

4

W

4

Y

22

V

Amino Acid Distribution

A: 35 R: 11 N: 12 D: 11 C: 0 E: 10 Q: 10 G: 25 H: 6 I: 8 L: 29 K: 22 M: 5 F: 12 P: 20 S: 14 T: 21 W: 4 Y: 4 V: 22

Length

281

Formula

C1352H2158N374O385S5

Mass

29972.58

PI

10.31

Net Charge

+13

Boman Index

46.03

Hydrophobicity

-0.132

Evidence 1 Activity

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.