TPDB

3D PDB MODEL

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TPDB ID TPDB49821

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP

Sequence_Type

standard

Has_Modification No

Description A 254-aa standard natural antifungal peptide sequence curated from dbAMP, with an available 3D structural model.

Sequence

ATAYTLNLANPSASQYSSFLDQIRNNVRDTSLIYGGTDVEVIGAPSTTDKFLRLNFQGPRGTVSLGLRRENLYVVAYLAMDNANVNRAYYFKNQITSAELTALFPEVVVANQKQLEYGEDYQAIEKNAKITTGDQSRKELGLGINLLITMIDGVNKKVRVVKDEARFLLIAIQMTAEAARFRYIQNLVTKNFPNKFDSENKVIQFQVSWSKISTAIFGDCKNGVFNKDYDFGFGKVRQAKDLQMGLLKYLGRPK

FASTA

>TPDB49821|Antifungal|length=254
ATAYTLNLANPSASQYSSFLDQIRNNVRDTSLIYGGTDVEVIGAPSTTDKFLRLNFQGPRGTVSLGLRRENLYVVAYLAMDNANVNRAYYFKNQITSAELTALFPEVVVANQKQLEYGEDYQAIEKNAKITTGDQSRKELGLGINLLITMIDGVNKKVRVVKDEARFLLIAIQMTAEAARFRYIQNLVTKNFPNKFDSENKVIQFQVSWSKISTAIFGDCKNGVFNKDYDFGFGKVRQAKDLQMGLLKYLGRPK

Formula C1282H2030N350O379S5

Absent Amino Acids H

Common Amino Acids L

Mass 28570.64

PI 9.73

Basic Residues 33

Acidic Residues 25

Hydrophobic Residues 110

Net Charge +8

Boman Index 42.33

Hydrophobicity -0.283

Aliphatic Index 89.84

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 23380

Absorbance 280nm 81.83

Polar Residues 75

number

21

A

14

R

20

N

14

D

1

C

11

E

14

Q

17

G

0

H

15

I

24

L

19

K

4

M

14

F

6

P

13

S

15

T

1

W

12

Y

19

V

Amino Acid Distribution

A: 21 R: 14 N: 20 D: 14 C: 1 E: 11 Q: 14 G: 17 H: 0 I: 15 L: 24 K: 19 M: 4 F: 14 P: 6 S: 13 T: 15 W: 1 Y: 12 V: 19

Length

254

Formula

C1282H2030N350O379S5

Mass

28570.64

PI

9.73

Net Charge

+8

Boman Index

42.33

Hydrophobicity

-0.283

Evidence 1 Activity

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.