TPDB

3D PDB MODEL

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TPDB ID TPDB49820

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP

Sequence_Type

standard

Has_Modification No

Description A 255-aa standard natural antifungal peptide sequence curated from dbAMP, with an available 3D structural model.

Sequence

ATAYTLNLANPSASQYSSFLDQIRNNVRDTSLIYGGTDVAVIGAPSTTDKFLRLNFQGPRGTVSLGLRRENLYVVAYLAMDNANVNRAYYFKNQITSAELTALFPEVVVANQKQLEYGEDYQAIEKNAKITTGDQSRKELGLGINLLITMIDGVNKKVRVVKDEARFLLIAIQMTAEAARFRYIQNLVTKNFPNKFDSENKVIQFQVSWSKISTAIFGDCKNGVFNKDYDFGFGKVRQAKDLQMGLLKYLGRPKS

FASTA

>TPDB49820|Antifungal|length=255
ATAYTLNLANPSASQYSSFLDQIRNNVRDTSLIYGGTDVAVIGAPSTTDKFLRLNFQGPRGTVSLGLRRENLYVVAYLAMDNANVNRAYYFKNQITSAELTALFPEVVVANQKQLEYGEDYQAIEKNAKITTGDQSRKELGLGINLLITMIDGVNKKVRVVKDEARFLLIAIQMTAEAARFRYIQNLVTKNFPNKFDSENKVIQFQVSWSKISTAIFGDCKNGVFNKDYDFGFGKVRQAKDLQMGLLKYLGRPKS

Formula C1283H2033N351O379S5

Absent Amino Acids H

Common Amino Acids L

Mass 28599.68

PI 9.81

Basic Residues 33

Acidic Residues 24

Hydrophobic Residues 111

Net Charge +9

Boman Index 40.27

Hydrophobicity -0.264

Aliphatic Index 89.88

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 23380

Absorbance 280nm 81.75

Polar Residues 76

number

22

A

14

R

20

N

14

D

1

C

10

E

14

Q

17

G

0

H

15

I

24

L

19

K

4

M

14

F

6

P

14

S

15

T

1

W

12

Y

19

V

Amino Acid Distribution

A: 22 R: 14 N: 20 D: 14 C: 1 E: 10 Q: 14 G: 17 H: 0 I: 15 L: 24 K: 19 M: 4 F: 14 P: 6 S: 14 T: 15 W: 1 Y: 12 V: 19

Length

255

Formula

C1283H2033N351O379S5

Mass

28599.68

PI

9.81

Net Charge

+9

Boman Index

40.27

Hydrophobicity

-0.264

Evidence 1 Activity

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.