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Peptide record

TPDB49624

Antifungal standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB49624
Antifungal
Anti-infective peptides
CAFPdb Peptipedia
standard
No
A 46-aa standard-residue antifungal peptide sequence curated from CAFPdb and Peptipedia, with an available 3D structural model.
Sequence
RECQSQSHRYKGACVHDTNCASVCQTEGFSGKCVGFRGRCFCTKHC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C208H325N71O65S8
ILMPW
C
5116.79
8.32
10
3
9
+4
2.56
-0.604
23.26
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1990
0.39
20
Residue Composition
number
2
A
4
R
1
N
1
D
8
C
2
E
3
Q
5
G
3
H
0
I
0
L
3
K
0
M
3
F
0
P
4
S
3
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 1 C: 8 E: 2 Q: 3 G: 5 H: 3 I: 0 L: 0 K: 3 M: 0 F: 3 P: 0 S: 4 T: 3 W: 0 Y: 1 V: 3
Chemical Descriptors
46 reviewed residue count
C208H325N71O65S8 sequence-only estimate (linear, free termini)
5116.79 sequence-only estimate (linear, free termini)
8.32 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.56 sequence-only estimate (linear, free termini)
-0.604 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antifungal
102 µg/mL

Target

F. oxysporum

Source & Reference

CAFPdb

Other

Due to a less amount isolated, its antifungal activity was tested only against F. oxysporum (IC50 102 ug/ml) and P. infestans (IC50 102 ug/ml), weaker than Ec-AMP-D1. However, the activity of Ec-AMP
Evidence 2 Activity

Activity

IC50
Antifungal
102 µg/mL

Target

P. infestans

Source & Reference

CAFPdb

Other

olated, its antifungal activity was tested only against F. oxysporum (IC50 102 ug/ml) and P. infestans (IC50 102 ug/ml), weaker than Ec-AMP-D1. However, the activity of Ec-AMP-D2 against the oomycete P. infest