Back to search

Peptide record

TPDB49623

Antifungal standard
46 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB49623
Antifungal
Anti-infective peptides
CAFPdb Peptipedia
standard
No
A 46-aa standard-residue antifungal peptide sequence curated from CAFPdb and Peptipedia, with an available 3D structural model.
Sequence
RECQSQSHRYKGACVHDTNCASVCQTEGFSGKCVGFRGRCFCTKAC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C205H323N69O65S8
ILMPW
C
5050.72
8.32
9
3
10
+4
2.42
-0.496
25.43
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1990
0.39
20
Residue Composition
number
3
A
4
R
1
N
1
D
8
C
2
E
3
Q
5
G
2
H
0
I
0
L
3
K
0
M
3
F
0
P
4
S
3
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 3 R: 4 N: 1 D: 1 C: 8 E: 2 Q: 3 G: 5 H: 2 I: 0 L: 0 K: 3 M: 0 F: 3 P: 0 S: 4 T: 3 W: 0 Y: 1 V: 3
Chemical Descriptors
46 reviewed residue count
C205H323N69O65S8 sequence-only estimate (linear, free termini)
5050.72 sequence-only estimate (linear, free termini)
8.32 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.42 sequence-only estimate (linear, free termini)
-0.496 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antifungal
15 µg/mL

Target

F. graminearum spore germination

Source & Reference

CAFPdb

Other

ainst C-graminicola, B-cinerea, and H-sativum (MIC> 30 ug/ml). The IC50 for inhibition of F. graminearum spore germination (IC50 15 ug/ml), for F. verticillioides (IC50 ~ 8.5 ug/ml), and for D. maydis (IC50 about 12.5 ug/ml). Th
Evidence 2 Activity

Activity

IC50
Antifungal
102 µg/mL

Target

F. oxysporum

Source & Reference

CAFPdb

Other

, and for D. maydis (IC50 about 12.5 ug/ml). The Ec-AMP-D1 was only weakly active against F. oxysporum (IC50 102 ug/ml). The Ec-AMP-D1 peptide inhibited hyphal development at IC50 of 25.5 ug/ml.