TPDB

3D PDB MODEL

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TPDB ID TPDB49553

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 245-aa standard natural antifungal peptide sequence curated from CAFPdb and dbAMP, with an available 3D structural model.

Sequence

MMKTLGAVLSLSLTILSFGGAHAAKMSFKNNCPYTVWPATQTSGKKPQLSTTGFKLAPHARFKLHTPVPWNGRFWARTGCSMDAYGKFVCATADCASGQVKCNGNGPIPPTTLAEFNIPAGGGKDFYDVSLVDGFNLPMSVNPQGGTGDCKTASCPKNVNKVCPRELQKKGANGKVVACLSACVAFQKPKYCCTPPQNTPETCPPTNYSQIFSHACPKAYSYAYDDKKGTFTCKGGPNYLITFCP

FASTA

>TPDB49553|Antifungal|length=245
MMKTLGAVLSLSLTILSFGGAHAAKMSFKNNCPYTVWPATQTSGKKPQLSTTGFKLAPHARFKLHTPVPWNGRFWARTGCSMDAYGKFVCATADCASGQVKCNGNGPIPPTTLAEFNIPAGGGKDFYDVSLVDGFNLPMSVNPQGGTGDCKTASCPKNVNKVCPRELQKKGANGKVVACLSACVAFQKPKYCCTPPQNTPETCPPTNYSQIFSHACPKAYSYAYDDKKGTFTCKGGPNYLITFCP

Formula C1162H1792N312O335S21

Absent Amino Acids

Common Amino Acids GP

Mass 26166.16

PI 9.03

Basic Residues 30

Acidic Residues 11

Hydrophobic Residues 84

Net Charge +15

Boman Index 24.84

Hydrophobicity -0.259

Aliphatic Index 54.61

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 30910

Absorbance 280nm 118.13

Polar Residues 83

number

22

A

4

R

14

N

8

D

16

C

3

E

8

Q

23

G

4

H

5

I

14

L

22

K

5

M

13

F

23

P

15

S

21

T

3

W

9

Y

13

V

Amino Acid Distribution

A: 22 R: 4 N: 14 D: 8 C: 16 E: 3 Q: 8 G: 23 H: 4 I: 5 L: 14 K: 22 M: 5 F: 13 P: 23 S: 15 T: 21 W: 3 Y: 9 V: 13

Length

245

Formula

C1162H1792N312O335S21

Mass

26166.16

PI

9.03

Net Charge

+15

Boman Index

24.84

Hydrophobicity

-0.259

Evidence 1 Activity

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.