TPDB

3D PDB MODEL

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TPDB ID TPDB49548

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 255-aa standard natural antifungal peptide sequence curated from CAFPdb and dbAMP, with an available 3D structural model.

Sequence

EQCGSQAGGATCPNCLCCSRFGWCGSTSDYCGDGCQSQCAGCGGGGTPVTPTPTPSGGGGVSSIVSRALFDRMLLHRNDGACQAKGFYTYDAFVAAAGAFPGFGTTGSTDTRKREVAAFLAQTSHETTGGWATAPDGAFAWGYCFKQERGATSNYCTPSAQWPCAPGKSYYGRGPIQLSHNYNYGPAGRAIGVDLLRNPDLVATDPTVSFKTAMWFWMTAQAPKPSSHAVITGQWSPSGTDRAAGRVPGFGVITN

FASTA

>TPDB49548|Antifungal|length=255
EQCGSQAGGATCPNCLCCSRFGWCGSTSDYCGDGCQSQCAGCGGGGTPVTPTPTPSGGGGVSSIVSRALFDRMLLHRNDGACQAKGFYTYDAFVAAAGAFPGFGTTGSTDTRKREVAAFLAQTSHETTGGWATAPDGAFAWGYCFKQERGATSNYCTPSAQWPCAPGKSYYGRGPIQLSHNYNYGPAGRAIGVDLLRNPDLVATDPTVSFKTAMWFWMTAQAPKPSSHAVITGQWSPSGTDRAAGRVPGFGVITN

Formula C1153H1726N330O357S17

Absent Amino Acids

Common Amino Acids G

Mass 26467.41

PI 7.77

Basic Residues 22

Acidic Residues 15

Hydrophobic Residues 86

Net Charge +3

Boman Index 14.93

Hydrophobicity -0.272

Aliphatic Index 45.69

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 52785

Absorbance 280nm 199.43

Polar Residues 85

number

30

A

12

R

7

N

11

D

14

C

4

E

11

Q

38

G

4

H

5

I

9

L

6

K

3

M

12

F

18

P

20

S

24

T

7

W

9

Y

11

V

Amino Acid Distribution

A: 30 R: 12 N: 7 D: 11 C: 14 E: 4 Q: 11 G: 38 H: 4 I: 5 L: 9 K: 6 M: 3 F: 12 P: 18 S: 20 T: 24 W: 7 Y: 9 V: 11

Length

255

Formula

C1153H1726N330O357S17

Mass

26467.41

PI

7.77

Net Charge

+3

Boman Index

14.93

Hydrophobicity

-0.272

Evidence 1 Activity

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.