TPDB

3D PDB MODEL

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TPDB ID TPDB49545

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 222-aa standard natural antifungal peptide sequence curated from CAFPdb and dbAMP, with an available 3D structural model.

Sequence

MQSVLVLAAIVPAALAQTYYGCYTEIPTRALTGAVPLIDYEAMTLADCEAHCTGFDLWGLEYGGECYCGNSLAQGSFPAFSTDCTMPCPGDATLTSVCGGPNRLSLYGTSETAPESLPYPHDPPVTTTQYEGCYTEVTEGARALAGASGFSLTDMTVGGCGGYCRDSGFTWFGLEYSAECYCGSELSVNSTLAAEEDCAMPCSGAAGEVCGGSNRLSVYQWV

FASTA

>TPDB49545|Antifungal|length=222
MQSVLVLAAIVPAALAQTYYGCYTEIPTRALTGAVPLIDYEAMTLADCEAHCTGFDLWGLEYGGECYCGNSLAQGSFPAFSTDCTMPCPGDATLTSVCGGPNRLSLYGTSETAPESLPYPHDPPVTTTQYEGCYTEVTEGARALAGASGFSLTDMTVGGCGGYCRDSGFTWFGLEYSAECYCGSELSVNSTLAAEEDCAMPCSGAAGEVCGGSNRLSVYQWV

Formula C1006H1511N253O335S21

Absent Amino Acids K

Common Amino Acids G

Mass 23182.82

PI 3.69

Basic Residues 7

Acidic Residues 25

Hydrophobic Residues 86

Net Charge -21

Boman Index 20.05

Hydrophobicity 0.073

Aliphatic Index 65.14

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 38360

Absorbance 280nm 165.47

Polar Residues 78

number

24

A

5

R

4

N

9

D

16

C

16

E

5

Q

27

G

2

H

3

I

19

L

0

K

5

M

6

F

13

P

18

S

21

T

3

W

14

Y

12

V

Amino Acid Distribution

A: 24 R: 5 N: 4 D: 9 C: 16 E: 16 Q: 5 G: 27 H: 2 I: 3 L: 19 K: 0 M: 5 F: 6 P: 13 S: 18 T: 21 W: 3 Y: 14 V: 12

Length

222

Formula

C1006H1511N253O335S21

Mass

23182.82

PI

3.69

Net Charge

-21

Boman Index

20.05

Hydrophobicity

0.073

Evidence 1 Activity

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.