TPDB

3D PDB MODEL

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TPDB ID TPDB49529

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 230-aa standard natural antifungal peptide sequence curated from CAFPdb and dbAMP, with an available 3D structural model.

Sequence

SGVFEVHNNCPYTVWAAATPVGGGRRLERGQSWWFWAPPGTKMARIWGRTNCNFDGAGRGWCQTGDCGGVLECKGWGKPPNTLAEYALNQFSNLDFWDISVIDGFNIPMSFGPTKPGPGKCHGIQCTANINGECPGSLRVPGGCNNPCTTFGGQQYCCTQGPCGPTELSRWFKQRCPDAYSYPQDDPTSTFTCTSWTTDYKVMFCPYGSAHNETTNFPLEMPTSTHEVAK

FASTA

>TPDB49529|Antifungal|length=230
SGVFEVHNNCPYTVWAAATPVGGGRRLERGQSWWFWAPPGTKMARIWGRTNCNFDGAGRGWCQTGDCGGVLECKGWGKPPNTLAEYALNQFSNLDFWDISVIDGFNIPMSFGPTKPGPGKCHGIQCTANINGECPGSLRVPGGCNNPCTTFGGQQYCCTQGPCGPTELSRWFKQRCPDAYSYPQDDPTSTFTCTSWTTDYKVMFCPYGSAHNETTNFPLEMPTSTHEVAK

Formula C1109H1628N306O331S20

Absent Amino Acids

Common Amino Acids G

Mass 25184.18

PI 6.42

Basic Residues 21

Acidic Residues 18

Hydrophobic Residues 68

Net Charge -1

Boman Index 22.63

Hydrophobicity -0.514

Aliphatic Index 40.30

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 66430

Absorbance 280nm 263.78

Polar Residues 80

number

12

A

9

R

14

N

9

D

16

C

9

E

9

Q

29

G

4

H

6

I

8

L

8

K

4

M

12

F

21

P

12

S

22

T

10

W

7

Y

9

V

Amino Acid Distribution

A: 12 R: 9 N: 14 D: 9 C: 16 E: 9 Q: 9 G: 29 H: 4 I: 6 L: 8 K: 8 M: 4 F: 12 P: 21 S: 12 T: 22 W: 10 Y: 7 V: 9

Length

230

Formula

C1109H1628N306O331S20

Mass

25184.18

PI

6.42

Net Charge

-1

Boman Index

22.63

Hydrophobicity

-0.514

Evidence 1 Activity

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.