TPDB

3D PDB MODEL

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TPDB ID TPDB49527

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 225-aa standard natural antifungal peptide sequence curated from CAFPdb and dbAMP, with an available 3D structural model.

Sequence

ATFEVRNNCPYTVWAASTPIGGGRRLDRGQTWVINAPRGTKMARIWGRTNCNFDGDGRGSCQTGDCGGVLQCTGWGKPPNTLAEYALDQFSNLDFWDISLVDGFNIPMTFAPTNPSGGKCHAIHCTANINGECPGSLRVPGGCNNPCTTFGGQQYCCTQGPCGPTDLSRFFKQRCPDAYSYPQDDPTSTFTCPSGSTNYRVVFCPNGVTSPNFPLEMPSSDEEAK

FASTA

>TPDB49527|Antifungal|length=225
ATFEVRNNCPYTVWAASTPIGGGRRLDRGQTWVINAPRGTKMARIWGRTNCNFDGDGRGSCQTGDCGGVLQCTGWGKPPNTLAEYALDQFSNLDFWDISLVDGFNIPMTFAPTNPSGGKCHAIHCTANINGECPGSLRVPGGCNNPCTTFGGQQYCCTQGPCGPTDLSRFFKQRCPDAYSYPQDDPTSTFTCPSGSTNYRVVFCPNGVTSPNFPLEMPSSDEEAK

Formula C1047H1576N300O330S19

Absent Amino Acids

Common Amino Acids G

Mass 24254.98

PI 5.55

Basic Residues 19

Acidic Residues 19

Hydrophobic Residues 63

Net Charge -3

Boman Index 29.52

Hydrophobicity -0.498

Aliphatic Index 44.67

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 37440

Absorbance 280nm 154.36

Polar Residues 82

number

12

A

12

R

16

N

13

D

16

C

6

E

9

Q

27

G

2

H

7

I

9

L

5

K

3

M

12

F

21

P

14

S

21

T

5

W

6

Y

9

V

Amino Acid Distribution

A: 12 R: 12 N: 16 D: 13 C: 16 E: 6 Q: 9 G: 27 H: 2 I: 7 L: 9 K: 5 M: 3 F: 12 P: 21 S: 14 T: 21 W: 5 Y: 6 V: 9

Length

225

Formula

C1047H1576N300O330S19

Mass

24254.98

PI

5.55

Net Charge

-3

Boman Index

29.52

Hydrophobicity

-0.498

Evidence 1 Activity

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.