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Peptide record

TPDB49523

Antifungal standard
171 amino acids
Basic Information
3D PDB MODEL
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TPDB49523
Antifungal
Anti-infective peptides
CAFPdb
standard
No
A 171-aa standard-residue antifungal peptide sequence curated from CAFPdb, with an available 3D structural model.
Sequence
MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C898H1469N245O237S11
L
19842.70
10.41
34
12
74
+19
1.43
-0.083
100.99
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17335
0.87
47
Residue Composition
number
10
A
10
R
4
N
5
D
6
C
7
E
11
Q
6
G
3
H
15
I
23
L
21
K
5
M
10
F
2
P
16
S
6
T
2
W
4
Y
5
V
Amino Acid Distribution
A: 10 R: 10 N: 4 D: 5 C: 6 E: 7 Q: 11 G: 6 H: 3 I: 15 L: 23 K: 21 M: 5 F: 10 P: 2 S: 16 T: 6 W: 2 Y: 4 V: 5
Chemical Descriptors
171 reviewed residue count
C898H1469N245O237S11 sequence-only estimate (linear, free termini)
19842.70 sequence-only estimate (linear, free termini)
10.41 sequence-only estimate (linear, free termini)
+19 sequence-only estimate (linear, free termini)
1.43 sequence-only estimate (linear, free termini)
-0.083 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

CAFPdb

Other

Supernatants from IL-1beta-treated memory T cells killed E. coli in an IL-26-dependent manner. Kills a vancomycin-resistant clinical isolate of E. faecalis (anti-VRE, 1 h incubation, 99.6% reduction in CFU at 50 ug/ml), S. aureus ATCC 6538 (94.6% CFU reduction at 50 ug/ml after 1h), MRSA, A. baumannii ATCC 19606 (99.8% at 50 ug/ml in 4h), and C. albicans (78.5% reduction at 50 ug/ml in 4 h) ( Hansen et al., 2021 ). Updated 7/2021