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Peptide record

TPDB49465

Antifungal standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB49465
Antifungal
Anti-infective peptides
Antifungipept CAFPdb DRAMP dbAMP Peptipedia
standard
No
A 50-aa standard natural antifungal peptide sequence curated from Antifungipept, CAFPdb, DRAMP, and other sources, with an available 3D structural model.
Sequence
RMCKTPSAKFKGYCVSSTNCKNVCRTEGFPTGSCDFHITSRKCYCYKPCP
Physicochemical Analysis
C240H375N69O70S9
QLW
C
5635.58
8.95
10
2
11
+7
7.90
-0.562
21.40
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
4970
88.19
23
Residue Composition
number
1
A
3
R
2
N
1
D
8
C
1
E
0
Q
3
G
1
H
1
I
0
L
6
K
1
M
3
F
4
P
5
S
5
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 8 E: 1 Q: 0 G: 3 H: 1 I: 1 L: 0 K: 6 M: 1 F: 3 P: 4 S: 5 T: 5 W: 0 Y: 3 V: 2
Chemical Descriptors
50
C240H375N69O70S9
5635.58
8.95
+7
7.90
-0.562
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
Antifungal
3.0 µM

Target

F. sporotrichiella

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
active against F. sporotrichiella (IC50 3.0 uM), S. cerevisiae (IC50 3.4 uM), P. gonapodyides (IC50 8.5 uM), Gram- P. carotovorum (IC50 1
Evidence 2 Activity

Activity

IC50
Antifungal
3.4 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against F. sporotrichiella (IC50 3.0 uM), S. cerevisiae (IC50 3.4 uM), P. gonapodyides (IC50 8.5 uM), Gram- P. carotovorum (IC50 12 uM), S. enteritidis (IC50 1
Evidence 3 Activity

Activity

IC50
Antifungal
8.5 µM

Target

P. gonapodyides

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against F. sporotrichiella (IC50 3.0 uM), S. cerevisiae (IC50 3.4 uM), P. gonapodyides (IC50 8.5 uM), Gram- P. carotovorum (IC50 12 uM), S. enteritidis (IC50 16.1 uM), P-aeruginosa (IC50 >20
Evidence 4 Activity

Activity

IC50
Antifungal
12 µM

Target

P. carotovorum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ichiella (IC50 3.0 uM), S. cerevisiae (IC50 3.4 uM), P. gonapodyides (IC50 8.5 uM), Gram- P. carotovorum (IC50 12 uM), S. enteritidis (IC50 16.1 uM), P-aeruginosa (IC50 >20 uM), Gram+ B. pumilus (IC50 9.3 uM
Evidence 5 Activity

Activity

IC50
Antifungal
16.1 µM

Target

S. enteritidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

revisiae (IC50 3.4 uM), P. gonapodyides (IC50 8.5 uM), Gram- P. carotovorum (IC50 12 uM), S. enteritidis (IC50 16.1 uM), P-aeruginosa (IC50 >20 uM), Gram+ B. pumilus (IC50 9.3 uM), and B. subtilis (IC50 14 uM)
Evidence 6 Activity

Activity

IC50
Antifungal
9.3 µM

Target

B. pumilus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

arotovorum (IC50 12 uM), S. enteritidis (IC50 16.1 uM), P-aeruginosa (IC50 >20 uM), Gram+ B. pumilus (IC50 9.3 uM), and B. subtilis (IC50 14 uM). IC50: half maximal inhibitory concentration. It also inhib
Evidence 7 Activity

Activity

IC50
Antifungal
14 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

teritidis (IC50 16.1 uM), P-aeruginosa (IC50 >20 uM), Gram+ B. pumilus (IC50 9.3 uM), and B. subtilis (IC50 14 uM). IC50: half maximal inhibitory concentration. It also inhibits insect alpha-amylase.