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Peptide record

TPDB49353

Antifungal standard
143 amino acids
Basic Information
3D PDB MODEL
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TPDB49353
Antifungal
Anti-infective peptides
Antifungipept CAFPdb Peptipedia
standard
No
A 143-aa standard natural antifungal peptide sequence curated from Antifungipept, CAFPdb, and Peptipedia, with an available 3D structural model.
Sequence
GVVLNVNPGKSLEEPAVKHLKVSPVNANEVPVLKELKSVQKTKSGDTLYGFVCTVGQIKTDSLGCVGSDSVAWPSEQNVELTVSCDKSNVGRIITYVEVHFVVSTQNVGCNVSAGSIGTSSIEVKVYAAGTNYLEYSSLFYIQ
Physicochemical Analysis
C674H1077N175O216S4
M
V
15216.25
5.54
13
13
56
-2
29.61
0.064
96.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14690
96.54
50
Residue Composition
number
6
A
1
R
9
N
4
D
4
C
9
E
5
Q
12
G
2
H
6
I
10
L
10
K
0
M
3
F
5
P
17
S
9
T
1
W
6
Y
24
V
Amino Acid Distribution
A: 6 R: 1 N: 9 D: 4 C: 4 E: 9 Q: 5 G: 12 H: 2 I: 6 L: 10 K: 10 M: 0 F: 3 P: 5 S: 17 T: 9 W: 1 Y: 6 V: 24
Chemical Descriptors
143
C674H1077N175O216S4
15216.25
5.54
-2
29.61
0.064
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

CAFPdb Antifungipept

Other

Active against C. albicans ATCC 76615 (MIC 2 ug/nL). AntibiofilmF: In a seprate study, it was found to ahve activity against both planktonic and biofilms of C. neoformans (MIC 4-16 ug/ml BIC80 16-32 ug/ml, and BEC80 64-128 ug/ml) ( Yang et al., 2022 ). BIC=biofilm inhibition concentration BEC=biofilm eradication concentration. Updated 2/2022 Net charge updated by APD 9/2022