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Peptide record

TPDB49190

Antifungal standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB49190
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 19-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
KWIRRIIRDYKKFFIKFII
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C129H203N33O23
ANCEQGHLMPSTV
I
2584.24
11.55
7
1
11
+6
1.84
0.032
123.16
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
2.70
1
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
6
I
0
L
4
K
0
M
3
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 6 L: 0 K: 4 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
19 reviewed residue count
C129H203N33O23 sequence-only estimate (linear, free termini)
2584.24 sequence-only estimate (linear, free termini)
11.55 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.84 sequence-only estimate (linear, free termini)
0.032 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antifungal
5.0 µM

Target

Candida albicans ATCC 90028

Source & Reference

NA

Other

active against C. albicans ATCC 90028 (MIC 5.0 uM), C-glabrata ATCC 90030 (MIC >20 uM), C. krusei ATCC 6258 (MIC 20 uM), C. parapsilosis ATC
Evidence 2 Activity

Activity

MIC
Antifungal
20 µM

Target

C. krusei ATCC 6258

Source & Reference

NA

Other

active against C. albicans ATCC 90028 (MIC 5.0 uM), C-glabrata ATCC 90030 (MIC >20 uM), C. krusei ATCC 6258 (MIC 20 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. tropicalis ATCC 750 (MIC 5.0 uM), C. guillermo
Evidence 3 Activity

Activity

MIC
Antifungal
10 µM

Target

C. parapsilosis ATCC 2209

Source & Reference

NA

Other

90028 (MIC 5.0 uM), C-glabrata ATCC 90030 (MIC >20 uM), C. krusei ATCC 6258 (MIC 20 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. tropicalis ATCC 750 (MIC 5.0 uM), C. guillermondii ATCC 6260 (MIC 2.5 uM). Minimal fu
Evidence 4 Activity

Activity

MIC
Antifungal
5.0 µM

Target

C. tropicalis ATCC 750

Source & Reference

NA

Other

030 (MIC >20 uM), C. krusei ATCC 6258 (MIC 20 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. tropicalis ATCC 750 (MIC 5.0 uM), C. guillermondii ATCC 6260 (MIC 2.5 uM). Minimal fungicidal concentration (MFC) is the s
Evidence 5 Activity

Activity

MIC
Antifungal
2.5 µM

Target

C. guillermondii ATCC 6260

Source & Reference

NA

Other

(MIC 20 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. tropicalis ATCC 750 (MIC 5.0 uM), C. guillermondii ATCC 6260 (MIC 2.5 uM). Minimal fungicidal concentration (MFC) is the same as MIC or higher. Biofilms:fungi:C. t