TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB49184

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.

Sequence

EKKPWARLRFKFKLLKGLAKKMK

FASTA

>TPDB49184|Antifungal|length=23
EKKPWARLRFKFKLLKGLAKKMK

Formula C136H230N38O26S1

Absent Amino Acids NDCQHISTYV

Common Amino Acids K

Mass 2845.62

PI 11.79

Basic Residues 10

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +9

Boman Index 5.10

Hydrophobicity -0.883

Aliphatic Index 76.52

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 193.28

Polar Residues 0

number

2

A

2

R

0

N

0

D

0

C

1

E

0

Q

1

G

0

H

0

I

4

L

8

K

1

M

2

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 8 M: 1 F: 2 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

23

Formula

C136H230N38O26S1

Mass

2845.62

PI

11.79

Net Charge

+9

Boman Index

5.10

Hydrophobicity

-0.883

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.41 µM

Target

Target Organism C. tropicalis ATCC 20962

Source & Reference

Database Source NA

Other

Evidence Text

active against fungi C. neoformans H99 (1.41 uM), C. albicans ATCC 10231 (44.98 uM), C. tropicalis ATCC 20962 (MIC 1.41 uM) (see ref), Gram- bacteria A. baumannii ATCC 19606 and 5 Carbapenem-resistant strains (MIC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism A. baumannii ATCC 19606 and 5 Carbapenem-resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

s ATCC 10231 (44.98 uM), C. tropicalis ATCC 20962 (MIC 1.41 uM) (see ref), Gram- bacteria A. baumannii ATCC 19606 and 5 Carbapenem-resistant strains (MIC 8 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa CMCC 10104 (MIC 16 ug/ml), K. pneumoniae

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Gram- bacteria A. baumannii ATCC 19606 and 5 Carbapenem-resistant strains (MIC 8 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa CMCC 10104 (MIC 16 ug/ml), K. pneumoniae ATCC 70060 (MIC 16 ug/ml), and Gr

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Pseudomonas aeruginosa CMCC 10104

Source & Reference

Database Source NA

Other

Evidence Text

19606 and 5 Carbapenem-resistant strains (MIC 8 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa CMCC 10104 (MIC 16 ug/ml), K. pneumoniae ATCC 70060 (MIC 16 ug/ml), and Gram+ S. aureusATCC 25923 (MIC 64 ug/ml) (

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 70060

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 8 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa CMCC 10104 (MIC 16 ug/ml), K. pneumoniae ATCC 70060 (MIC 16 ug/ml), and Gram+ S. aureusATCC 25923 (MIC 64 ug/ml) ( Yang et al., 2024 ). MBC values were eith

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism S. aureusATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

aeruginosa CMCC 10104 (MIC 16 ug/ml), K. pneumoniae ATCC 70060 (MIC 16 ug/ml), and Gram+ S. aureusATCC 25923 (MIC 64 ug/ml) ( Yang et al., 2024 ). MBC values were either identical or higher, indicating direct kill