TPDB

3D PDB MODEL

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TPDB ID TPDB49165

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.

Sequence

GHYCNFSVTPKFKRW

FASTA

>TPDB49165|Antifungal|length=15
GHYCNFSVTPKFKRW

Formula C88H124N24O20S1

Absent Amino Acids ADEQILM

Common Amino Acids KF

Mass 1870.16

PI 10.20

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +3

Boman Index -0.32

Hydrophobicity -0.827

Aliphatic Index 19.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 373.76

Polar Residues 5

number

0

A

1

R

1

N

0

D

1

C

0

E

0

Q

1

G

1

H

0

I

0

L

2

K

0

M

2

F

1

P

1

S

1

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 2 M: 0 F: 2 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 1

Length

15

Formula

C88H124N24O20S1

Mass

1870.16

PI

10.20

Net Charge

+3

Boman Index

-0.32

Hydrophobicity

-0.827

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.78 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 3.12 uM), Gram- S. enterica (MIC 0.78 uM), P. aeruginosa (MIC 25 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 3.12 uM), Gram- S. enterica (MIC 0.78 uM), P. aeruginosa (MIC 25 uM), V-parahaemolyticus (MIC >50

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.78 µM

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 3.12 uM), Gram- S. enterica (MIC 0.78 uM), P. aeruginosa (MIC 25 uM), V-parahaemolyticus (MIC >50 uM), and C. albicans (MIC 6.25 uM

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 3.12 uM), Gram- S. enterica (MIC 0.78 uM), P. aeruginosa (MIC 25 uM), V-parahaemolyticus (MIC >50 uM), and C. albicans (MIC 6.25 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

. enterica (MIC 0.78 uM), P. aeruginosa (MIC 25 uM), V-parahaemolyticus (MIC >50 uM), and C. albicans (MIC 6.25 uM).