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Peptide record

TPDB49163

Antifungal standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB49163
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 13-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
FLKIIGKLLSGLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C70H123N15O15
ARNDCEQHMPTWYV
L
1414.84
10.60
2
0
8
+2
-1.91
1.646
210.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
5
L
2
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 5 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13 reviewed residue count
C70H123N15O15 sequence-only estimate (linear, free termini)
1414.84 sequence-only estimate (linear, free termini)
10.60 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-1.91 sequence-only estimate (linear, free termini)
1.646 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus aureus NCTC 6538 or MRSA ATCC 12493

Source & Reference

NA

Other

Active against Gram+ S. aureus NCTC 6538 or MRSA ATCC 12493 (MIC 1 uM), E. faecalis NCTC 12697 (MIC 2 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATC
Evidence 2 Activity

Activity

MIC
Antifungal
2 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

NA

Other

Active against Gram+ S. aureus NCTC 6538 or MRSA ATCC 12493 (MIC 1 uM), E. faecalis NCTC 12697 (MIC 2 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 32 uM), P. aeruginosa
Evidence 3 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

aureus NCTC 6538 or MRSA ATCC 12493 (MIC 1 uM), E. faecalis NCTC 12697 (MIC 2 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 32 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), and yeast C.
Evidence 4 Activity

Activity

MIC
Antifungal
32 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

NA

Other

12493 (MIC 1 uM), E. faecalis NCTC 12697 (MIC 2 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 32 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), and yeast C. albicans ATCC 10231 (MIC 32 uM). Also
Evidence 5 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

697 (MIC 2 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 32 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), and yeast C. albicans ATCC 10231 (MIC 32 uM). Also inhibited biofilm formation:bacteria:
Evidence 6 Activity

Activity

MIC
Antifungal
32 µM

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

uM), K. pneumoniae ATCC 43816 (MIC 32 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), and yeast C. albicans ATCC 10231 (MIC 32 uM). Also inhibited biofilm formation:bacteria:S. aureus (MBIC 2 uM MBEC 32 uM) biofilms:ba