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Peptide record

TPDB49160

Antifungal standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB49160
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 35-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
RLCTNCCAGRKGCNYYSADGTFICEGESDPNNPKA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C153H237N47O54S5
QHMWV
C
3759.15
6.16
4
4
8
-0
2.35
-0.749
30.86
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
3230
0.86
15
Residue Composition
number
3
A
2
R
4
N
2
D
5
C
2
E
0
Q
4
G
0
H
1
I
1
L
2
K
0
M
1
F
2
P
2
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 4 D: 2 C: 5 E: 2 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 2 M: 0 F: 1 P: 2 S: 2 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
35 reviewed residue count
C153H237N47O54S5 sequence-only estimate (linear, free termini)
3759.15 sequence-only estimate (linear, free termini)
6.16 sequence-only estimate (linear, free termini)
-0 sequence-only estimate (linear, free termini)
2.35 sequence-only estimate (linear, free termini)
-0.749 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

NA

Other

39% growth inhibition of C. albicans was not peptide-dose dependent from 25 to 200 ug/ml. C. buinensis inhibition 37% at 100 ug/ml and 70% at 200 ug/ml. no effect on C.tropicalis or C.parapsilosis at 200 ug/ml. cell viability loss when treated at 200 ug/ml (53 uM) for 24 h: C. albicans and C. buinensis. CaCPin-II inhibited alpha-amylase activity.