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Peptide record

TPDB49120

Antifungal standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB49120
Antifungal
Anti-infective peptides
AFP-GFuse Antifungipept CAFPdb DRAMP Peptipedia
standard
No
A 36-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
AFIQLSKPCISDKECSIVKNYRARCRKGYCVRRRIR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C185H315N63O48S4
HMTW
R
4318.17
10.67
11
2
12
+9
3.32
-0.597
75.83
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3230
0.75
11
Residue Composition
number
2
A
7
R
1
N
1
D
4
C
1
E
1
Q
1
G
0
H
4
I
1
L
4
K
0
M
1
F
1
P
3
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 7 N: 1 D: 1 C: 4 E: 1 Q: 1 G: 1 H: 0 I: 4 L: 1 K: 4 M: 0 F: 1 P: 1 S: 3 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
36 reviewed residue count
C185H315N63O48S4 sequence-only estimate (linear, free termini)
4318.17 sequence-only estimate (linear, free termini)
10.67 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
3.32 sequence-only estimate (linear, free termini)
-0.597 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

DRAMP CAFPdb Antifungipept

Other

Active against C. albicans strains WO-1 and Sc5314 (MIC 11 and 12.5 ug/ml).