TPDB

3D PDB MODEL

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TPDB ID TPDB49091

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.

Sequence

RLQLNYKGKMWCPGW

FASTA

>TPDB49091|Antifungal|length=15
RLQLNYKGKMWCPGW

Formula C87H130N24O19S2

Absent Amino Acids ADEHIFSTV

Common Amino Acids GLKW

Mass 1880.26

PI 10.20

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +3

Boman Index -1.97

Hydrophobicity -0.853

Aliphatic Index 52.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 12490

Absorbance 280nm 664.27

Polar Residues 4

number

0

A

1

R

1

N

0

D

1

C

0

E

1

Q

2

G

0

H

0

I

2

L

2

K

1

M

0

F

1

P

0

S

0

T

2

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 2 K: 2 M: 1 F: 0 P: 1 S: 0 T: 0 W: 2 Y: 1 V: 0

Length

15

Formula

C87H130N24O19S2

Mass

1880.26

PI

10.20

Net Charge

+3

Boman Index

-1.97

Hydrophobicity

-0.853

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.78 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 6.25 uM), Gram- S. enterica (MIC 1.56 uM), P. aeruginosa (MIC 25 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 6.25 uM), Gram- S. enterica (MIC 1.56 uM), P. aeruginosa (MIC 25 uM), V.parahaemolyticus (NA), and

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µM

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 6.25 uM), Gram- S. enterica (MIC 1.56 uM), P. aeruginosa (MIC 25 uM), V.parahaemolyticus (NA), and fungi C. albicans (MIC 25 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

B. subtilis (MIC 0.78 uM), S. aureus MRSA (MIC 6.25 uM), Gram- S. enterica (MIC 1.56 uM), P. aeruginosa (MIC 25 uM), V.parahaemolyticus (NA), and fungi C. albicans (MIC 25 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

S. enterica (MIC 1.56 uM), P. aeruginosa (MIC 25 uM), V.parahaemolyticus (NA), and fungi C. albicans (MIC 25 uM).