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Peptide record

TPDB49077

Antifungal standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB49077
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 45-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
LCVSYSVRPSCKFVGRSNWKRNTCLEWCDQLFLFCFLIGGEMANS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C232H352N62O63S6
H
CLS
5210.08
8.14
5
3
18
+2
1.15
0.158
73.56
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
12740
2.45
16
Residue Composition
number
1
A
3
R
3
N
1
D
5
C
2
E
1
Q
3
G
0
H
1
I
5
L
2
K
1
M
4
F
1
P
5
S
1
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 3 D: 1 C: 5 E: 2 Q: 1 G: 3 H: 0 I: 1 L: 5 K: 2 M: 1 F: 4 P: 1 S: 5 T: 1 W: 2 Y: 1 V: 3
Chemical Descriptors
45 reviewed residue count
C232H352N62O63S6 sequence-only estimate (linear, free termini)
5210.08 sequence-only estimate (linear, free termini)
8.14 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.15 sequence-only estimate (linear, free termini)
0.158 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

NA

Other

active against Gram+ B.subtilis IA274 (- insignificant), C. michiganensis (+++), B.cereus 905 (-), C. fangii (+++ very significant), B. subtilis 330-2 (+ significant), B.subtilis RIK1285 (-), B.subtilis 168 (-), Gram- X. oryzae pv. Oryzae (+), X. oryzae pv. Oryzicola (+++), R. solanacearum (+), X. campestris pv. Holcicola (-). Bacteriostatic.