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Peptide record

TPDB49048

Antifungal standard
61 amino acids
Basic Information
3D PDB MODEL
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TPDB49048
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 61-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
DVLSGKYKGPCYFGIIPCFVRGCKPKLFDAHRKLCIKLCKQEGFKSGHCSNFFKFQCWCTR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C322H491N87O77S8
M
K
7069.46
9.47
14
3
20
+9
1.24
-0.185
55.90
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
8980
1.27
17
Residue Composition
number
1
A
3
R
1
N
2
D
8
C
1
E
2
Q
6
G
2
H
3
I
4
L
9
K
0
M
7
F
3
P
3
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 2 C: 8 E: 1 Q: 2 G: 6 H: 2 I: 3 L: 4 K: 9 M: 0 F: 7 P: 3 S: 3 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
61 reviewed residue count
C322H491N87O77S8 sequence-only estimate (linear, free termini)
7069.46 sequence-only estimate (linear, free termini)
9.47 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
1.24 sequence-only estimate (linear, free termini)
-0.185 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

NA

Other

inhibition zone assay: active against fungi N. crassa CGMCC 3.1605 (CL 26.01 uM), G. candidum CCTCC AY 93038 (CL 35.05 uM), C. albicans 2.4116(CL 29.64 uM), Gram+ B. megaterium CGMCC 1.0459 (CL 8.97 uM), B. subtilis CGMCC 1.2428 (CL 10.91 uM), M. luteus CGMCC 1.0290 (CL 8.67 uM), Penicillin-resistant S. aureus P1383 (CL 8.07 uM), S. mutans ATCC 1.2499 (CL 8.45 uM), S. salivarius ATCC 1.2498 (CL 8.93 uM), and S. sanguinis ATCC 1.2497 (CL 5.16 uM). CL= lethal concentration.