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Peptide record

TPDB49030

Antifungal standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB49030
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 23-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
GFLDVIKHVGKAALSVVSHLINE
Physicochemical Analysis
C112H184N30O31
RCQMPTWY
V
2446.88
7.94
4
2
12
+0
4.36
0.717
143.91
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
1
E
0
Q
2
G
2
H
2
I
3
L
2
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 2 L: 3 K: 2 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
23
C112H184N30O31
2446.88
7.94
+0
4.36
0.717
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antifungal
13.09 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 13.09 uM), S. aureus (MIC 26.18 uM), and C. albicans (MIC 52.36 uM). Parasites: T. cruzi Trypomasti
Evidence 2 Activity

Activity

MIC
Antifungal
26.18 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E. coli (MIC 13.09 uM), S. aureus (MIC 26.18 uM), and C. albicans (MIC 52.36 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.55 uM) or Am
Evidence 3 Activity

Activity

MIC
Antifungal
52.36 µM

Target

Candida albicans

Source & Reference

NA

Other

Active against E. coli (MIC 13.09 uM), S. aureus (MIC 26.18 uM), and C. albicans (MIC 52.36 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.55 uM) or Amastigotes (IC50 30.65 uM), P. fa
Evidence 4 Activity

Activity

IC50
Antifungal
1.55 µM

Target

T. cruzi Trypomastigotes

Source & Reference

NA

Other

coli (MIC 13.09 uM), S. aureus (MIC 26.18 uM), and C. albicans (MIC 52.36 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.55 uM) or Amastigotes (IC50 30.65 uM), P. falciparum NF54 (IC50 13.86 uM) or TM90C2B (IC50 4.87
Evidence 5 Activity

Activity

IC50
Antifungal
13.86 µM

Target

P. falciparum NF54

Source & Reference

NA

Other

6 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.55 uM) or Amastigotes (IC50 30.65 uM), P. falciparum NF54 (IC50 13.86 uM) or TM90C2B (IC50 4.87 uM), L. Mexicana (IC50 0.09 uM).
Evidence 6 Activity

Activity

IC50
Antifungal
0.09 µM

Target

L. Mexicana

Source & Reference

NA

Other

mastigotes (IC50 30.65 uM), P. falciparum NF54 (IC50 13.86 uM) or TM90C2B (IC50 4.87 uM), L. Mexicana (IC50 0.09 uM).