TPDB

3D PDB MODEL

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TPDB ID TPDB49025

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.

Sequence

FLSLIPKAISAVSALAKHL

FASTA

>TPDB49025|Antifungal|length=19
FLSLIPKAISAVSALAKHL

Formula C94H159N23O23

Absent Amino Acids RNDCEQGMTWY

Common Amino Acids AL

Mass 1979.44

PI 10.60

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +2

Boman Index -0.82

Hydrophobicity 1.232

Aliphatic Index 159.47

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

4

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

2

I

4

L

2

K

0

M

1

F

1

P

3

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 4 K: 2 M: 0 F: 1 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1

Length

19

Formula

C94H159N23O23

Mass

1979.44

PI

10.60

Net Charge

+2

Boman Index

-0.82

Hydrophobicity

1.232

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 4 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), A.baumannii BAA 747 (MIC > 128 uM), K. pneumonia ATC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Escherichia coli ATCC 8739

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 4 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), A.baumannii BAA 747 (MIC > 128 uM), K. pneumonia ATCC 43816 (MIC 8 uM), P. aeruginosa AT

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism K. pneumonia ATCC 43816

Source & Reference

Database Source NA

Other

Evidence Text

12493 (MIC 4 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), A.baumannii BAA 747 (MIC > 128 uM), K. pneumonia ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 32 uM), and fungi C. albicans (MIC 32 uM). Rapid killing at

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 9027

Source & Reference

Database Source NA

Other

Evidence Text

8739 (MIC 8 uM), A.baumannii BAA 747 (MIC > 128 uM), K. pneumonia ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 32 uM), and fungi C. albicans (MIC 32 uM). Rapid killing at 2xMIC. It binds to LPS. inhibit biof

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

8 uM), K. pneumonia ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 32 uM), and fungi C. albicans (MIC 32 uM). Rapid killing at 2xMIC. It binds to LPS. inhibit biofilms:bacteria (S. aureus and E. col