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Peptide record

TPDB49021

Antifungal standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB49021
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 16-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
CSSGSLWRLIRRFLRR
Physicochemical Analysis
C88H148N32O20S1
ANDEQHKMPTYV
R
2006.41
12.58
5
0
6
+5
-0.76
-0.313
97.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
274.12
4
Residue Composition
number
0
A
5
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
3
L
0
K
0
M
1
F
0
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 0 M: 0 F: 1 P: 0 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
16
C88H148N32O20S1
2006.41
12.58
+5
-0.76
-0.313
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antifungal
6.25-12.5 µg/mL

Target

C. neoformans

Source & Reference

NA

Other

/ml) ( Vélez et al., 2024 ). Additional antifungal assays against 10 strains Cryptococcus C. neoformans (MIC 6.25-12.5 ug/ml), 10 strains C. gattii (MIC 3.125-12.5 ug/ml), Candida 28 strains C. parapsilosis (MIC 0.3
Evidence 2 Activity

Activity

MIC
Antifungal
3.125-12.5 µg/mL

Target

C. gattii

Source & Reference

NA

Other

al assays against 10 strains Cryptococcus C. neoformans (MIC 6.25-12.5 ug/ml), 10 strains C. gattii (MIC 3.125-12.5 ug/ml), Candida 28 strains C. parapsilosis (MIC 0.391-12.5 ug/ml), 18 strains C. glabrata (MIC 0
Evidence 3 Activity

Activity

MIC
Antifungal
0.391-12.5 µg/mL

Target

C. parapsilosis

Source & Reference

NA

Other

ns (MIC 6.25-12.5 ug/ml), 10 strains C. gattii (MIC 3.125-12.5 ug/ml), Candida 28 strains C. parapsilosis (MIC 0.391-12.5 ug/ml), 18 strains C. glabrata (MIC 0.391-12..5 ug/ml) 1 strain at 50 ug/ml, 17 strains C. tropi
Evidence 4 Activity

Activity

MIC
Antifungal
0.391-3.125 µg/mL

Target

C. tropicalis

Source & Reference

NA

Other

5 ug/ml), 18 strains C. glabrata (MIC 0.391-12..5 ug/ml) 1 strain at 50 ug/ml, 17 strains C. tropicalis (MIC 0.391-3.125 ug/ml), 4 strains C. dubliniensis and C. krusei (MIC 0.391 ug/ml) ( Firacative et al., 2025 ). R
Evidence 5 Activity

Activity

MIC
Antifungal
0.391 µg/mL

Target

C. krusei

Source & Reference

NA

Other

50 ug/ml, 17 strains C. tropicalis (MIC 0.391-3.125 ug/ml), 4 strains C. dubliniensis and C. krusei (MIC 0.391 ug/ml) ( Firacative et al., 2025 ). Radial diffusion assay: inhibited 6 clinical strains P. aeru