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Peptide record

TPDB48971

Antifungal standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB48971
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 12-aa standard-residue antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
WRLRIRWRWIRK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C87H137N31O13
ANDCEQGHMFPSTYV
R
1825.24
13.00
6
0
6
+6
4.87
-1.358
97.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
9.04
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
12 reviewed residue count
C87H137N31O13 sequence-only estimate (linear, free termini)
1825.24 sequence-only estimate (linear, free termini)
13.00 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.87 sequence-only estimate (linear, free termini)
-1.358 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

active against P. aeruginosa PAO1 (MIC 3 ug/ml), E. coli (MIC 1.6 ug/ml), S. typhimurium (MIC 6 ug/ml), S. aureus (MIC 6 ug/ml), S. epide
Evidence 2 Activity

Activity

MIC
Antifungal
1.6 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

active against P. aeruginosa PAO1 (MIC 3 ug/ml), E. coli (MIC 1.6 ug/ml), S. typhimurium (MIC 6 ug/ml), S. aureus (MIC 6 ug/ml), S. epidermidis (MIC 0.8 ug/ml), E
Evidence 3 Activity

Activity

MIC
Antifungal
6 µg/mL

Target

S. typhimurium

Source & Reference

NA

Other

active against P. aeruginosa PAO1 (MIC 3 ug/ml), E. coli (MIC 1.6 ug/ml), S. typhimurium (MIC 6 ug/ml), S. aureus (MIC 6 ug/ml), S. epidermidis (MIC 0.8 ug/ml), E. faecalis ATCC29212 (MIC 12 u
Evidence 4 Activity

Activity

MIC
Antifungal
6 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

P. aeruginosa PAO1 (MIC 3 ug/ml), E. coli (MIC 1.6 ug/ml), S. typhimurium (MIC 6 ug/ml), S. aureus (MIC 6 ug/ml), S. epidermidis (MIC 0.8 ug/ml), E. faecalis ATCC29212 (MIC 12 ug/ml), and C. albicans (M
Evidence 5 Activity

Activity

MIC
Antifungal
0.8 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

3 ug/ml), E. coli (MIC 1.6 ug/ml), S. typhimurium (MIC 6 ug/ml), S. aureus (MIC 6 ug/ml), S. epidermidis (MIC 0.8 ug/ml), E. faecalis ATCC29212 (MIC 12 ug/ml), and C. albicans (MIC 3 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

NA

Other

), S. typhimurium (MIC 6 ug/ml), S. aureus (MIC 6 ug/ml), S. epidermidis (MIC 0.8 ug/ml), E. faecalis ATCC29212 (MIC 12 ug/ml), and C. albicans (MIC 3 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

Candida albicans

Source & Reference

NA

Other

(MIC 6 ug/ml), S. epidermidis (MIC 0.8 ug/ml), E. faecalis ATCC29212 (MIC 12 ug/ml), and C. albicans (MIC 3 ug/ml).