TPDB

3D PDB MODEL

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TPDB ID TPDB48969

Activity

Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AFP-GFuse Antifp

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural antifungal peptide sequence curated from AFP-GFuse and Antifp, with an available 3D structural model.

Sequence

HQWRIRVAVRRH

FASTA

>TPDB48969|Antifungal|length=12
HQWRIRVAVRRH

Formula C71H116N30O14

Absent Amino Acids NDCEGLKMFPSTY

Common Amino Acids R

Mass 1613.89

PI 12.88

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index 3.55

Hydrophobicity -1.175

Aliphatic Index 89.17

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 340.79

Polar Residues 1

number

1

A

4

R

0

N

0

D

0

C

0

E

1

Q

0

G

2

H

1

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2

Length

12

Formula

C71H116N30O14

Mass

1613.89

PI

12.88

Net Charge

+4

Boman Index

3.55

Hydrophobicity

-1.175

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source NA

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 25 ug/ml), S. aureus (MIC 25 ug/ml), S. epide

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 25 ug/ml), S. aureus (MIC 25 ug/ml), S. epidermidis (MIC 12 ug/ml),

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 25 ug/ml), S. aureus (MIC 25 ug/ml), S. epidermidis (MIC 12 ug/ml), E-faecalis ATCC29212 (MIC >25 u

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

P. aeruginosa PAO1 (MIC 50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 25 ug/ml), S. aureus (MIC 25 ug/ml), S. epidermidis (MIC 12 ug/ml), E-faecalis ATCC29212 (MIC >25 ug/ml), and C. albicans (MI

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

0 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 25 ug/ml), S. aureus (MIC 25 ug/ml), S. epidermidis (MIC 12 ug/ml), E-faecalis ATCC29212 (MIC >25 ug/ml), and C. albicans (MIC 25 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 25 ug/ml), S. epidermidis (MIC 12 ug/ml), E-faecalis ATCC29212 (MIC >25 ug/ml), and C. albicans (MIC 25 ug/ml).